The San Francisco 49ers' three-game home stand continues Sunday against the Arizona Cardinals.
Sunday's game should be an interesting challenge for the 49ers in what might prove to be their toughest game of the year so far. Arizona looked great in a 26-14 Week 1 win over the Los Angeles Chargers. They didn't look as good in a 31-7 blowout loss to the Seattle Seahawks.
Now the 49ers must face their division foe without defensive end Nick Bosa as their injuries stack up along the defensive line. If they can't stop the run against Arizona it could be a long day for a defensive unit that has had the benefit of playing with big leads. Sunday may be the first time that group is in a tight game for all four quarters.
Here's where to watch Week 3:
Stream
49ers vs. Cardinals
What channel is 49ers vs. Cardinals on today?
- TV Channel: Fox
- Livestream: Fubo (free trial)
49ers vs. Cardinals game time today
- Date: Sunday, Sept. 26, 2026
- Start time: 1:05 pm Pacific Time
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49ers vs. Cardinals predictions, picks, odds
- Match-up prediction: Almost all of the expert picks we analyzed had San Francisco winning Sunday's matchup. We're not picking against the 49ers here, but this one should be significantly closer than the first two weeks where San Francisco has won by a combined 42 points. Arizona's offense will be able to move the ball against a banged up 49ers defense, but the 49ers offense is dialed in enough to come out on top in a shootout. 49ers 31, Cardinals 28
- Spread: 49ers -7.5
- Over/under: Over 48.5 (-108), Under 48.5 (-110)
- Moneyline: 49ers -400, Cardinals +310
More 49ers: Nick Bosa injury update: Will 49ers DE play vs. Cardinals?
This article originally appeared on Niners Wire: Where to watch 49ers vs. Cardinals today: Time, TV channel for Week 3
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