The San Francisco 49ers are sizable favorites heading into their Week 6 Monday Night Football matchup against the Washington Commanders.
San Francisco opened as a 7.5-point favorite over Washington, according to BetMGM, with the two teams set to meet at Levi's Stadium on Monday night.
The 49ers are 5-0 after edging the Seattle Seahawks, 32-29, on Sunday to remain one of three undefeated teams in the NFL. Washington, meanwhile, is 1-3-1 after settling for a 27-27 tie with the New York Giants.
Here's a look at the opening betting lines for the 49ers' Week 6 matchup against the Commanders.
- Point spread: 49ers -7.5 (-108), Commanders +7.5 (-110)
- Over/under: 50.5 points (Over -112, Under -105)
- Moneyline: 49ers -400, Commanders +320
The 50.5-point over/under suggests oddsmakers expect a relatively high-scoring matchup between the NFC opponents. But considering how the 49ers have fared this season
with five consecutive wins with at least 24 points scored, the over/under and point spread indicate San Francisco could put up a lot more points.
The 49ers will look to keep their perfect record intact against a Commanders team coming off a frustrating tie. Washington will have an opportunity to bounce back, but it faces a difficult challenge on the road against one of the league's remaining undefeated teams. The 49ers also continue to have injury problems, with Deebo Samuel now nursing a hamstring injury.
This article originally appeared on Niners Wire: 49ers open as heavy primetime favorites vs. Commanders
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