49ers vs Cardinals live updates: Score, highlights, analysis

The San Francisco 49ers continue their three-game homestand Sunday vs. the Arizona Cardinals at Levi's Stadium. Week 3 will be a tough one for the 49ers as they face a divisional rival without defensive end Nick Bosa on an already depleted defensive line. The 49ers' run defense has struggled to star

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San Francisco 49ers continue their three-game homestand Sunday vs. the Arizona Cardinals at Levi's Stadium.

Week 3 will be a tough one for the 49ers as they face a divisional rival without defensive end Nick Bosa on an already depleted defensive line. The 49ers' run defense has struggled to start the year

Hit refresh for the latest highlights, injury news, key plays and instant breakdown as the 49ers take on the Cardinals in their Week 3 meeting:

49ers vs Cardinals score

49ers vs Cardinals predictions, betting odds

02:41 PM ET, September 27 2026, Kyle Madson

Odds via BetMGM.

49ers 31, Cardinals 28. We're not picking against the 49ers here, but this one should be significantly closer than the first two weeks where San Francisco has won by a combined 42 points. Arizona's offense will be able to move the ball against a banged up 49ers defense, but the 49ers offense is dialed in enough to come out on top in a shootout.
Spread: 49ers (-7.5)
Total O/U: 48.5
Moneyline: 49ers (-375)