The Detroit Lions (6-2) meet the New England Patriots (5-4) from FC Bayern Munich Stadium in Munich, Germany.
It's the Lions' third all-time international game and the first for Detroit since 2015. Detroit enters having won four straight and in need of another victory in order to keep pace in an NFC North division that features all four teams with winning records.
The Lions used four Jake Bates field goals and an 8-yard touchdown run from Jahmyr Gibbs to top the Miami Dolphins last week from Hard Rock Stadium.
Meanwhile, the Patriots were embarrassed by Jordan Love and the Green Bay Packers. Love threw for 372 yards and three touchdowns as the Patriots allowed a franchise record amount of points in Gillette Stadium in a 45-27 loss.
As kickoff approaches,
here's a look at the latest betting odds. Plus, our best bet and a prediction for the game.
Lions vs. Patriots betting odds, best bet, prediction
Detroit is seeking its second all-time win in an international game. The Lions topped the Atlanta Falcons, 22-21, in Week 8 of the 2014 NFL season. Detroit erased a 21-0 deficit en route to that win over Atlanta, winning with a 48-yard Matt Prater field goal as time expired.
The Lions should be on guard that they will get New England's best after the Patriots got rocked by the Packers last week.
New England and Drake Maye have been turnover prone. The Patriots are tied with the Indianapolis Colts for last in turnover differential at minus-11. New England has turned it over an NFL-leading 19 times this season. Maye has 18 touchdowns, but he also leads the NFL with 11 interceptions. Dating to the start of the 2025 playoffs, Maye has 21 giveaways in 13 games. That figures to be a helper for a Detroit defense that enters ranked last in passing yards allowed.
New England gives up a bunch through the air, too. The Patriots rank 25th in passing yards allowed, surrendering 231.9 through the air per game.
Detroit understands the sense of urgency they need to play with in the NFC North, and the Lions are eager to get their offense kicked back into high gear.
The best bet: Lions giving the 2.5 points.
Some other bets to consider: Amon-Ra St. Brown as your anytime TD scorer. St. Brown's odds are -145 as an anytime TD scorer. You know that the Lions want to feature St. Brown in this game given St. Brown's German heritage. I'd think about St. Brown over 82.5 receiving yards as well. Those odds are -115.
Prediction: Lions 27, Patriots 24
For more Lions coverage, follow us on X, @TheLionsWire, and give our Facebook page a like. Follow Josh on X, @JoshOnLions
This article originally appeared on Lions Wire: Lions vs Patriots betting odds, best bet, prediction
Advertiser disclosure: USA TODAY may earn a commission when you sign up through links on this page. Commissions never influence our editorial coverage or rankings. Offers and odds were accurate at publication and are subject to change; terms apply — see the operator’s site. This is general information, not betting, legal or financial advice. To the fullest extent permitted by law, USA TODAY is not liable for losses arising from your use of it.
Must be 21+ (18+ where permitted). Sports betting and casino gaming are not legal everywhere; complying with the laws where you are located is your responsibility. Gamble only with funds you can afford to lose. Gambling problem? Help is available 24/7 — call or text 1-800-GAMBLER, or call the National Problem Gambling Helpline at 1-800-MY-RESET. State helplines and responsible gaming resources.
