Florida football will host the Ole Miss Rebels inside Ben Hill Griffin Stadium this weekend for a Week 4 battle between two ranked SEC teams. Ahead of Saturday's matchup in the Swamp, BetMGM's early betting lines are looking bullish on the Orange and Blue.
The Gators bring a 3-0 record into play after beating Auburn in the SEC opener last weekend, and are ranked 22nd by the US LBM Coaches Poll and 21st by the AP Top 25. Meanwhile, the Rebels are also a perfect 3-0 after they triumphed over LSU on Saturday, and are ranked sixth in the Coaches Poll and fourth in the AP Poll after three games.
The all-time series between the two conference charter members dating back to 1926 is knotted up at 13-13-1. Ole Miss won the last meeting at Vaught–Hemingway
Stadium last year, 34-24, but Florida was victorious in the three prior matchups and has prevailed in the last two played in Gainesville.
Stream Florida vs. Ole Miss with Fubo free trial
Florida vs. Ole Miss odds, money line, over/under
Odds courtesy of BetMGM as of Monday, Sept. 21
- Moneyline: +130 / -160
- Spread: Florida by 3.5
- Over/under: 60.5
Florida vs. Ole Miss predictions, picks for college football
Florida passed its first major test last weekend against Auburn, and while Jon Sumrall and Co. out-duked the Tigers, it was far from a perfect performance — particularly the penalty issue that has once again reared its head. The offense overall still looks potent and the defense, despite a few letdowns, appears to be rounding into form.
Ole Miss represents the Gators' biggest challenge so far this season and is a formidable foe. But with a raucous Swamp crowd behind them at home, they should undoubtedly have the edge. But the key will be improvements in both team discipline and defensive play — if Florida can play a clean, tight game, they should prevail for their first 4-0 start since 2019.
PREDICTION: Florida 35, Ole Miss 31
Follow us @GatorsWire on X, formerly known as Twitter, as well as Bluesky, and like our page on Facebook to follow ongoing coverage of Florida Gators news, notes and opinions.
This article originally appeared on Gators Wire: Florida vs. Ole Miss predictions, picks, odds: Early lines for Week 4
Our editors independently choose our recommendations. Some content is produced with paid support from a third party, however our editorial decisions remain independent. If you buy through our links, the USA TODAY Network may earn a commission. Prices and availability may change.
Advertiser disclosure: USA TODAY may earn a commission when you sign up through links on this page. Commissions never influence our editorial coverage or rankings. Offers and odds were accurate at publication and are subject to change; terms apply — see the operator’s site. This is general information, not betting, legal or financial advice. To the fullest extent permitted by law, USA TODAY is not liable for losses arising from your use of it.
Must be 21+ (18+ where permitted). Sports betting and casino gaming are not legal everywhere; complying with the laws where you are located is your responsibility. Gamble only with funds you can afford to lose. Gambling problem? Help is available 24/7 — call or text 1-800-GAMBLER, or call the National Problem Gambling Helpline at 1-800-MY-RESET. State helplines and responsible gaming resources.













