Week 10 kicks off with a showdown in the NFC East.
The New York Giants (5-2-1) have been one of the league's biggest surprises and now leads the division despite losing quarterback Jaxson Dart early in the year. They'll play host to the Washington Commanders (2-5-1) in JJ McCarthy's first home start at quarterback.
The Commanders have just one win since Week 3, which came against the injury-plagued Eagles, but they tied the Giants when these two met in Landover in Week 5.
If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds from FanDuel.
Giants vs. Commanders game odds:
All NFL odds via FanDuel
- Spread: Washington Commanders +1.5 (+100), New York Giants -1.5 (-120)
- Money Line: Washington Commanders +114, New York Giants -134
- Over-Under: Over 41.5 (+100), Under 41.5 (-120)
Giants vs. Commanders injury report:
The final injury report for the New York Giants and the Washington Commanders ahead of their game at the Meadowlands on Thursday night.
pic.twitter.com/NO0AgGzk54
— Ralph Vacchiano (@RalphVacchiano) November 11, 2026
Giants vs. Commanders prediction, pick:
McCarthy has been solid enough to keep the Giants in playoff contention, and he's good to go after exiting with an injury on Sunday. The Giants will also get Cam Skattebo back, which should help a run game that has struggled. Their defense remains a borderline top-10 unit, especially against the pass, which gives me confidence against a Washington team that doesn't have much outside of Jayden Daniels, who has been solid this year.
Washington's own defense has some problems and has been one of the league's worst against the run. It's hard for me to see a path to the Commanders winning this game, and it's a tight spread in New York. Feeling pretty good about this pick.
Prediction: Giants 27, Commanders 17
Best Bet: Giants -1.5
Giants vs. Commanders channel, start time, streaming:
Time: 8:15 p.m. ET
Stream: Prime Video
This article originally appeared on For The Win: Giants vs. Commanders: Week 10 NFL betting odds, prediction, pick
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