Another week of NFL football is upon us, and it should be a good one.
Week 6 begins on Thursday night with a fascinating interconference showdown between the defending champion Seattle Seahawks and the Denver Broncos. Then, on Sunday, Caleb Williams is likely to make his return to the field as the Bears take on a resurgent Atlanta Falcons team.
Elsewhere on the Sunday slate, the Ravens and Browns square off in an AFC North matchup that could be much more pivotal than anyone expected coming into the year, while the Eagles look to shrug off some recent tough losses at home against the Panthers.
We have a showdown of blue-blood franchises on Sunday night as the Packers square off against the Cowboys, while on Monday night, the red-hot 49ers look to
remain unbeaten against a Commanders team coming off a baffling tie against the Giants.
Our panel of experts is back to give you their picks against the spread for all matchups on the Week 6 slate.
All odds via BetMGM
Seattle Seahawks at Denver Broncos (Thursday Night Football)
Opening Line: Seahawks -1.5
Grimes: Seahawks -2.5
Especially if Pat Surtain is ruled out.
Curtis: Seahawks -2.5
The Broncos are feeling very mid lately.
Zeglinski: Seahawks -2.5
The Seahawks are PISSED after blowing a big game to their biggest rival. I, uh, think it's a problem that Bo Nix is afraid to play quarterback.
D'Andrea: Seahawks -2.5
Pieces of Bo Nix's confidence will be scattered across the greater Denver area.
Nettuno: Seahawks -2.5
I just don't really trust Bo Nix, man.
Houston Texans vs. Jacksonville Jaguars (in London)
Opening Line: Jaguars -1.5
Grimes: Texans +2.5
Houston might finally be gaining some momentum.
Curtis: Jaguars -2.5
The Jags are contenders, while the Texans are still figuring things out.
Zeglinski: Jaguars -2.5
Jacksonville might be the AFC's best and most complete team. I'll believe in the Texans only when they give me a reason to.
D'Andrea: Jaguars -2.5
I don't believe the Texans are fixed yet, and I don't think a trip to Great Britain is going to help.
Nettuno: Jaguars -2.5
This is going to be a tough game for Jacksonville, but I think it will win by at least a field goal.
Chicago Bears at Atlanta Falcons
Opening Line: Bears -3
Grimes: Falcons +2.5
Atlanta's defense has been surprisingly solid.
Curtis: Bears -2.5
Caleb back! The Bears' offense should benefit.
Zeglinski: Bears -2.5
Caleb Williams is back and almost certainly heard all the crap-talking about his hamstring strain. Chicago in a dome shootout with its talisman leading the way sounds about right.
D'Andrea: Falcons +2.5
Michael Penix Jr. performs well from a clean pocket. The Bears lack the personnel to get to him with a four-man rush, and when they blitz he can dump it off to Bijan Robinson, the absolute last man you want to see one-on-one in the open field.
Nettuno: Bears -2.5
If Caleb plays I think they'll be fine here.
Baltimore Ravens at Cleveland Browns
Opening Line: Ravens -6.5
Grimes: Browns +5.5
Cleveland usually plays Baltimore tougher than you would imagine.
Curtis: Ravens -5.5
Assuming Lamar Jackson returns, I could see Baltimore winning by a bunch.
Zeglinski: Ravens -5.5
Right about now is where the Browns fall back to Earth and where the otherwise healthy Ravens start building momentum for January.
D'Andrea: Browns +5.5
Cleveland is regressing back to the mean, but I'm not betting against a home team getting points in an AFC North rivalry.
Nettuno: Ravens -5.5
If Lamar plays I think they'll be fine here.
Pittsburgh Steelers at Tampa Bay Buccaneers
Opening Line: Buccaneers -1.5
Grimes: Steelers -2.5
Let's see Tampa against an actual NFL defense.
Curtis: Steelers -2.5
Hey, the Steelers are starting to look like a playoff team! I'll take them against a Bucs team that's struggling.
Zeglinski: Steelers -2.5
Pittsburgh has the sorry Buccaneers, Saints, and Browns on their table over the next three weeks. Sigh. They just might start 6-2.
D'Andrea: Steelers -2.5
Tampa blitzes at a top three rate and generates pressure at a bottom-four rate. Even a 42-year-old Aaron Rodgers can take advantage of that.
Nettuno: Steelers -2.5
Pittsburgh's defense is just a bit better than Dallas'.
New York Jets at New England Patriots
Opening Line: Patriots -9.5
Grimes: Patriots -7
The Pats might be finding their footing.
Curtis: Patriots -7
A divisional game, yes, but the Pats are coming into their own after an uneven start to the year.
Zeglinski: Patriots -7
It sounds like A.J. Brown is coming back right as Drake Maye regains his MVP-caliber form. Godspeed to the Jets.
D'Andrea: Patriots -7
The Jets are better than they were. They aren't good yet.
Nettuno: Patriots -7
Pats seem to be figuring things out.
New Orleans Saints at New York Giants
Opening Line: Giants -2.5
Grimes: Giants +1
Jameis revenge game?
Curtis: Giants +1
Listen, man. This Giants team is a giant shrug emoji right now, but they should be able to win at home after last week's wild ride.
Zeglinski: Saints -1
I am confident in nothing about the mid Giants or their goofy middling quarterback. The Saints are bad, too, but this is a spot where they can get back on track.
D'Andrea: Saints -1
New York is a strange collection of mismatched parts. So is New Orleans, but less so.
Nettuno: Saints -1
I don't trust either of these teams, guess I'll take the home team in what's essentially a pick 'em.
Carolina Panthers at Philadelphia Eagles
Opening Line: Eagles -6.5
Grimes: Eagles +1
Philly is possibly getting some important pieces back from injury.
Curtis: Panthers -1
The Eagles are a mess right now, so I'll take the offensively talented team coming off the bye.
Zeglinski: Panthers -1
Every week, people keep saying the Eagles are due for a course-correction game. And every week, they fall flat on their face. I like Carolina to keep its positive momentum going.
D'Andrea: Panthers -1
Carolina's coming off a bye week. Philadelphia just flew back from an incredibly deflating loss in London.
Nettuno: Eagles +1
Ending aside, a banged up Philly played the Jags a lot tougher than many expected.
Tennessee Titans at Indianapolis Colts
Opening Line: Colts -3.5
Grimes: Titans +7
The Colts will win but Tennessee has played better teams closer.
Curtis: Colts -7
The Titans continue to look lost, so you can't bet on them until they don't.
Zeglinski: Colts -7
The Titans have scored 58 points through five games. Total.
D'Andrea: Colts -7
The spread's gotta be at least two touchdowns before I consider the Titans.
Nettuno: Colts -7
This line is probably too big but the Titans are really bad.
Arizona Cardinals at Los Angeles Rams
Opening Line: Rams -13.5
Grimes: Rams -13
The Rams are ticked off after that MNF loss.
Curtis: Rams -13
A get-right game is just what the doctors ordered.
Zeglinski: Rams -13
Oh dear football gods: Matthew Stafford, Davante Adams, and Puka Nacua against that Arizona secondary. Phew.
D'Andrea: Cardinals +13
Arizona can backdoor cover its way to some betting heartbreak.
Nettuno: Rams -13
Big-time bounce-back spot here for Los Angeles.
Buffalo Bills at Las Vegas Raiders
Opening Line: Bills -6.5
Grimes: Bills -4.5
Did the Raiders finally get exposed?
Curtis: Bills -4.5
Josh Allen continues to be unstoppable.
Zeglinski: Bills -4.5:
Buffalo kind of reeks of another paper-tiger regular season, but that also means a two-score win over the pretender Raiders.
D'Andrea: Bills -4.5
This is Buffalo's first trip to Vegas since 2020. Bills fans are gonna turn up for this one.
Nettuno: Bills -4.5
The Raiders aren't actually that good, shocker.
Los Angeles Chargers at Kansas City Chiefs
Opening Line: Chiefs -2.5
Grimes: Chiefs -8
Chiefs coming off a bye. This could get ugly.
Curtis: Chiefs -8
A reminder that the Chargers are coached by Jim Harbaugh and are winless. Unreal.
Zeglinski: Chiefs -8
Seriously, is Jim Harbaugh's job gonna make it to Halloween at this rate? I don't see where the Chargers their first win!
D'Andrea: Chiefs -8
I don't know what Jim Harbaugh can change to fix things. I know several ways it can get worse, however.
Nettuno: Chargers +8
Purely trying to zig while my colleagues zag here. I think the Chargers can at least cover this before losing in frustrating fashion again.
Dallas Cowboys at Green Bay Packers (Sunday Night Football)
Opening Line: Packers -3
Grimes: Packers -1
I don't feel good about it but I would feel even worse taking Dallas after the way Jalon Daniels shredded them.
Curtis: Packers -1
Two teams with flaws, but Green Bay does the job at home.
Zeglinski: Cowboys +1
The Cowboys, as funny as they are, are still better than we think and the Packers are still worse than we think coming off a blowout win. They'll meet in the middle here.
D'Andrea: Packers -1
This is a perfect empty calories primetime game. Give me something stupid like 45-42.
Nettuno: Packers -1
These teams are both kind of goofy, but the Cowboys' defense is as bad as advertised.
Washington Commanders at San Francisco 49ers (Monday Night Football)
Opening Line: 49ers -5.5
Grimes: Commanders +7.5
Jayden Daniels just has a way of hanging around in games.
Curtis: 49ers -7.5
After last week, the Commanders might be in their heads. A perfect time for the 49ers to trounce them.
Zeglinski: 49ers -7.5
Can't wait to see who Jayden Daniels points a finger at this time after the 49ers coax out a terrible performance from him and the Washington offense.
D'Andrea: 49ers -7.5.
Fine, I'll believe in the Niners, I guess.
Nettuno: 49ers -7.5
Bad vibes in Washington right now.
This article originally appeared on For The Win: NFL picks against the spread for Week 6 from our expert staff
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