After a long offseason, the 2026 NFL season is finally here. The campaign begins on Wednesday night with a matchup of historical significance.
For the third time in NFL history, we'll see a Super Bowl rematch in Week 1 as the New England Patriots travel to Seattle to take on the reigning champion Seahawks. They'll hope for a better result than when these teams met in February, and Seattle rolled to a 29-13 win in Santa Clara
.Both teams are expected to be among the best in their respective conferences this season, but only one will start 1-0.
If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds, courtesy of BetMGM.
Seahawks vs. Patriots game odds:
All college football odds via BetMGM
- Spread: Seahawks -3 (-118), Patriots +3 (-102)
- Money Line: Seahawks -185, Patriots +150
- Over-Under: Over 44.5 (-108), Under 44.5 (-110)
Seahawks vs. Patriots injury report:
Per Monday's reports
Seahawks
Did not participate
- S Ty Okada (hamstring)
Limited participation
- S Nick Emmanwori (ankle)
- WR Tory Horton (hamstring)
- T Josh Jones (knee)
Full participation
- TE AJ Barner (oblique)
- G Anthony Bradford (knee)
- CB Julian Neal (quadricep)
- RB Emanuel Wilson (hamstring)
Patriots
Did not participate
- C Ben Brown (knee, out)
- RB TreVeyon Henderson (ankle)
Full participation
- DT Christian Barmore (knee)
Seahawks vs. Patriots prediction, pick:
Seattle doesn't bring everyone back from its Super Bowl run (*cough cough* Kenneth Walker *cough*), but the Seahawks return the bulk of their elite defense and locked up cornerback Devon Witherspoon on a massive new deal earlier in training camp. The rest of the secondary is a bit of a question mark, as rookie safety Bud Clark will miss the entire season with a broken ankle, while Nick Emmanwori remains questionable with an ankle injury of his own.
New England, meanwhile, added some new toys in the passing game for Drake Maye in AJ Brown and Romeo Doubs, while veteran safety addition Kevin Byard III should prove to be a major help coming off a seven-interception season.
I'm not sure anything has markedly changed for New England up front, however, and Seattle's defensive line should feast here again. I expect Sam Darnold and Co. to do enough on offense to win this one fairly comfortably.
Prediction: Seahawks 24, Patriots 13
Best Bet: Seahawks -3
Seahawks vs. Patriots channel, start time, streaming:
Time: 8:20 p.m. ET
TV: NBC
Stream: NBC Sports app, Peacock
This article originally appeared on For The Win: Seahawks vs. Patriots: Week 1 NFL betting odds, prediction, pick
Our editors independently choose our recommendations. Some content is produced with paid support from a third party, however our editorial decisions remain independent. If you buy through our links, the USA TODAY Network may earn a commission. Prices and availability may change.
Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. Terms apply, see operator site for Terms and Conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN). Must be 21 or older to gamble. Sports betting and gambling are not legal in all locations. Be sure to comply with laws applicable where you reside. It is your sole responsibility to act in accordance with your local laws.
Gambling involves risk. Please only gamble with funds that you can comfortably afford to lose. While we do our utmost to offer good advice and information we cannot be held responsible for any loss that may be incurred as a result of gambling. We do our best to make sure all the information that we provide on this site is correct. However, from time to time mistakes will be made and we will not be held liable. Please check any stats or information if you are unsure how accurate they are. No guarantees are made with regards to results or financial gain. All forms of betting carry financial risk and it is up to the individual to make bets with or without the assistance of information provided on this site and we cannot be held responsible for any loss that may be incurred as a result of following the betting tips provided on this site. Past performances do not guarantee success in the future and betting odds fluctuate from one minute to the next. The material contained on this site is intended to inform, entertain and educate the reader and in no way represents an inducement to gamble legally or illegally or any sort of professional advice.
Prediction Markets: Certain prediction markets are event contracts regulated by the U.S. Commodity Futures Trading Commission (CFTC) or other applicable regulatory authorities and are legally distinct from traditional gambling and sports betting. Eligibility requirements to participate in prediction markets differ from those for sports betting and gambling — you may be required to be 18 or older (or such other age as the applicable platform requires) and to satisfy other eligibility criteria established by the relevant platform and governing law. Prediction market trading involves financial risk and may not be available in all jurisdictions. The legal and regulatory status of prediction markets varies by jurisdiction and by platform. It is your sole responsibility to confirm that participation is lawful where you reside and to comply with all applicable laws and platform terms.
