The Chargers open up the 2026 regular season against the Cardinals this Sunday at SoFi Stadium.
Here are the current betting odds for the Week 1 game, courtesy of DraftKings Sportsbook:
Over/under: The total is set at 47.5 points, with the Under slightly favored at -118 juice compared to -102 for the Over.
Point spread: Los Angeles is favored at -9.5 (-115), while Arizona sits at +9.5 (-105).
Moneyline: The Chargers are priced at -520 to win outright, while the underdog Cardinals sit between +390.
Trends to know
- The Chargers are 3-3 against the spread (ATS) in their last six games head-to-head against the Cardinals.
- The Over is 4-2 in the last six meetings between Los Angeles and Arizona.
- The Bolts finished the 2025 regular season with a 5-5 ATS record over their final 10 games (8-9 ATS overall).
- Only seven of the Chargers' 17 games hit the Over during the 2025 season.
- Last season, the Chargers went 1-1 ATS when favored by 9.5 points or more
This article originally appeared on Chargers Wire: Chargers vs. Cardinals odds: Spread, moneyline, over/under analysis
Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence
over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. Terms apply, see operator site for Terms and Conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN). Must be 21 or older to gamble. Sports betting and gambling are not legal in all locations. Be sure to comply with laws applicable where you reside. It is your sole responsibility to act in accordance with your local laws.
Gambling involves risk. Please only gamble with funds that you can comfortably afford to lose. While we do our utmost to offer good advice and information we cannot be held responsible for any loss that may be incurred as a result of gambling. We do our best to make sure all the information that we provide on this site is correct. However, from time to time mistakes will be made and we will not be held liable. Please check any stats or information if you are unsure how accurate they are. No guarantees are made with regards to results or financial gain. All forms of betting carry financial risk and it is up to the individual to make bets with or without the assistance of information provided on this site and we cannot be held responsible for any loss that may be incurred as a result of following the betting tips provided on this site. Past performances do not guarantee success in the future and betting odds fluctuate from one minute to the next. The material contained on this site is intended to inform, entertain and educate the reader and in no way represents an inducement to gamble legally or illegally or any sort of professional advice.
Prediction Markets: Certain prediction markets are event contracts regulated by the U.S. Commodity Futures Trading Commission (CFTC) or other applicable regulatory authorities and are legally distinct from traditional gambling and sports betting. Eligibility requirements to participate in prediction markets differ from those for sports betting and gambling — you may be required to be 18 or older (or such other age as the applicable platform requires) and to satisfy other eligibility criteria established by the relevant platform and governing law. Prediction market trading involves financial risk and may not be available in all jurisdictions. The legal and regulatory status of prediction markets varies by jurisdiction and by platform. It is your sole responsibility to confirm that participation is lawful where you reside and to comply with all applicable laws and platform terms.
