The Chargers are 7-point road underdogs to the Bills in Week 3 of the 2026 regular season. The over/under is 50.5 points, per DraftKings Sportsbook.
That means oddsmakers are taking bets on whether the two teams will score more or fewer than 50.5 points combined.
My score prediction for the game is a 30-21 Bills win, with a combined total of 51 points. So, if I were putting money based on my prediction, I’d bet the Over.
Nate Davis (USA Today): Bills
Jarrett Bell (USA Today): Bills
Mike Clay (ESPN): Bills
Matt Bowen (ESPN): Bills
Pete Prisco (CBS Sports): Bills
Bill Bender (Sporting News): Bills
NFL.com Staff: Bills (5-0)
Bleacher Report: Bills
As for game picks, most analysts are picking Buffalo to win.
Sunday's game will begin at 10:00 a.m. PT and air
on Fox.
This article originally appeared on Chargers Wire: Chargers vs. Bills picks: Will LA upset Buffalo in Week 3?
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