The FSU Seminoles will have another shot to win their first road game since 2023 when they play the Louisville Cardinals on Friday in L&N Federal Credit Union Stadium. The game is scheduled to start at 7 p.m. ET and will be on ESPN.
FSU (3-2, 1-1 ACC) is fresh off a 38-7 win over the Virginia Cavaliers in their best performance of the season. Ashton Daniels and offensive lineman André Otto were both named ACC Players of the Week after dominant performances. Daniels ran for a program-record five touchdowns, and Otto received an 86% job grade with seven knockdown blocks.
Louisville (2-3, 1-2 ACC) is teetering after back-to-back losses to the Wake Forest Demon Deacons and NC State Wolfpack, which have them below .500. Despite their struggles, all
three of their losses have been by just three points.
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FSU leads the series against Louisville 18-6 and is 7-3 on the road. The two have not played since 2023, with the Seminoles winning the last two meetings, including a 16-6 victory in the 2023 ACC Championship game.
Here is an early look at the betting odds and a prediction for Friday's game between FSU and Louisville.
FSU vs. Louisville odds, money line, over/under
Odds courtesy of BetMGM as of Oct. 5
- Moneyline: FSU (+145), Virginia (-175)
- Spread: Louisville by 4
- Over/under: 58.5
FSU vs. Louisville predictions, pick
FSU didn't just upset the Virginia Cavaliers on Saturday; they blew them out. They are looking to pull off the upset victory for the second straight week on Friday night when they play the Louisville Cardinals on the road. While FSU is trending up and Louisville is trending down, it will be tough to get the win.
The Seminoles have not won on the road since the 2023 season, losing their last 10 road games, and their streak will grow to 11 on Friday. Louisville has the talent to get back on track and will pull out the win in a shootout.
Prediction: Louisville 38, FSU 31
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This article originally appeared on FSU Wire: FSU opens as underdogs against Louisville
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