The NFL is an "any given Sunday" kind of league, which means the Seattle Seahawks cannot overlook the Arizona Cardinals. Last week, the Cardinals reminded everyone that any team can win one game as they upset the Los Angeles Chargers 26-14 on the road. Actually, they borderline bullied the Chargers.
Now the Seahawks are going into an evironment where they'll face an Arizona team emboldened by their upset in Week 1 and hungry to snap their current nine-game losing streak against the Seahawks. What better time to do so than to hand the reigning Super Bowl champions their first loss of the season. Can they do so again? Or will Drew Lock once again guide the Seahawks to victory?
We at Seahawks Wire, as well as our friend Jess Root of Cards Wire, give
our official picks and predictions below.
Stream Seahawks vs Cardinals
Seahawks vs Cardinals odds, money line, over/under
Odds courtesy of BetMGM as of Saturday, September 19th, 2026
- Moneyline: Seahawks -200, Cardinals +170
- Spread: Seahawks -3.5
- Over/under: 40.5
Seahawks vs Cardinals predictions, picks for NFL Week 2
Kole Musgrove - Seahawks Wire Managing Editor
Seahawks 20, Cardinals 13: Seahawks vs. Cardinals games are usually competitive the first time these teams meet during the season. I think this game is tight, with Seattle feeling in control the whole time. Seattle will likely be even more conservative than usual with Drew Lock under center. Not because they don't trust him, but because they are going to ensure he is put in the best position to succeed. The Seahawks don't need to be flashy, they just need to survive. The differnce in this game will obviously be the Dark Side Defense. No one can run on the Seahawks, and if Arizona becomes one-dimensional then Seattle's defensive line is going to feast on Jacoby Brissett.
Justin Melo - Seahawks Wire Contributor
Seahawks 23, Cardinals 13: The Seattle Seahawks will ride another strong defensive performance to victory with Drew Lock at quarterback.
Matt Legros - Seahawks Wire Contributor
Seahawks 27, Cardinals 13: Drew Lock delivers another steady performance for the Seahawks, and the run game delivers two touchdowns in the NFC West showdown. The Seahawks’ elite defense limits Jacoby Brissett, Trey McBride and company to secure the win.
Jess Root - Cards Wire Managing Editor
Seahawks 24, Cardinals 13: Seattle's defense will be too much for the Cardinals' promising offense, and Arizona's defense will not be prepared for the physical dogfight the Seahawks will bring.
Seahawks vs Cardinals time, TV channel today
- Kickoff time: 1:25 pm Pacific Time
- TV Channel: FOX
- Livestream: Fubo (free trial)
This article originally appeared on Seahawks Wire: Seahawks vs Cardinals predictions, picks, odds: Who wins Week 2 NFL game?
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