The Clemson Tigers are on the road for the second straight Saturday in Week 10 of the 2026 college football season. Dabo Swinney's team heads north to face the Syracuse Orange at JMA Wireless Dome.
The Tigers are hoping this year's matchup against the Orange goes a lot better than the last one. Syracuse thoroughly dominated Clemson in stunning fashion en route to a 34-21 win at Death Valley on Sept. 20, 2025. It was just the second time Syracuse had beaten the Tigers since joining the ACC in 2013.
Clemson (5-3, 3-2 ACC) is coming off a 36-24 win over rival Florida State in Week 9 at Doak Campbell Stadium in Tallahassee. Tait Reynolds threw two touchdown passes and rushed for another on a 79-yard score late in the game to send the Tigers to their
10th win in 11 games against the Seminoles.
Syracuse (4-4, 2-4) pulled its biggest upset of the season in Week 9. Coach Fran Brown's team knocked off previously 19th-ranked SMU on a late Steve Angeli touchdown pass to tight end Noah Meyers with 17 seconds left for a thrilling 30-27 win at JMA Wireless Dome (formerly Carrier Dome).
Here are the early game odds for Clemson-Syracuse.
Clemson vs. Syracuse Week 10 game odds:
Odds according to FanDuel as of Monday, Nov. 2:
- Spread: Clemson (-2.5)
- Moneyline: Clemson (-134), Syracuse (+112)
- Over/under: 50.5
Updated ACC football standings entering loaded Week 10 slate
— Clemson Wire (@Clemson_Wire) November 1, 2026
📸 Scott Taetsch, USA TODAY Sports https://t.co/HcqfBeXjQq pic.twitter.com/do2XgqVkpc
Clemson football schedule 2026
Kickoff for Clemson-Syracuse is noon ET Saturday. The game will be televised on ESPN2.
All times Eastern.
- Sept. 5: at LSU Tigers (L, 51-10)
- Sept. 12: vs. Georgia Southern Eagles (W, 22-7)
- Sept. 19: vs. North Carolina Tar Heels (W, 28-20)
- Sept. 25: at California Golden Bears (W, 24-10)
- Oct. 3: vs. Miami Hurricanes (L, 41-13)
- Oct. 17: vs. Charleston Southern Buccaneers (W, 37-0)
- Oct. 24: vs. Virginia Tech Hokies (L, 20-16)
- Oct. 31: at Florida State Seminoles (W, 36-24)
- Nov. 7: at Syracuse Orange, noon ET, ESPN2
- Nov. 14: vs. Georgia Tech Yellow Jackets, 12:30 p.m., The CW
- Nov. 20: at Duke Blue Devils, 7:30 p.m., ESPN
- Nov. 28: vs. South Carolina Gamecocks, TBA
Record: 5-3 overall, 3-2.
Dabo Swinney is ready to build Clemson back up to top of college football
— Clemson Wire (@Clemson_Wire) November 2, 2026
📸 Ken Ruinard / USA Today Network , USA TODAY Network via Reuters Co https://t.co/0yyK3HcwSL pic.twitter.com/LrlILqEM61
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This article originally appeared on Clemson Wire: Who has the edge? Latest odds for Clemson vs. Syracuse in Week 10 game
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