The Arizona Cardinals are back at it on Sunday. They have a road division game against the 2-0 San Francisco 49ers, against whom they have lost six of their last eight meetings.
The Cardinals lost 31-7 to the Seattle Seahawks last week after a 26-14 Week 1 win over the LA Chargers. They struggled on offense and had no answer for Seahawks receiver Jaxon Smith-Njigba.
The 49ers have had two three-score wins so far, beating the LA Rams 28-7 in Australia and the Miami Dolphins at home 35-13. Quarterback Brock Purdy has been fantastic, throwing five touchdown passes in two games and rushing for another. They have allowed only 20 total points, but have been decimated by injuries on the defensive line.
Follow along for highlights, injury news, key plays,
and instant breakdown as the Cardinals take on the 49ers in a pivotal NFC West showdown.
Cardinals vs. 49ers score
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Cardinals vs. 49ers weather forecast
11:43 AM ET, September 27 2026, Jess Root- The weather is expected to be perfect in Santa Clara, California. It is expected to be sunny and 71 degrees with no chance of rain.
- The wind is expected to be a light at 7 MPH from the northwest.
How to watch Cardinals vs. 49ers: TV channel, streaming info
11:41 AM ET, September 27 2026, Jess Root- Cardinals vs. 49ers airs live on FOX and will be streamed on Fubo and NFL+
- Sunday, Sept. 27
- 4:05 p.m. ET (1:05 p.m. Arizona time)
This article originally appeared on Cards Wire: Cardinals vs. 49ers live updates: Score, highlights, predictions, analysis
