The Arizona Cardinals and Detroit Lions play on Sunday in Week 5 at State Farm Stadium in Glendale, Arizona. Kickoff is at 4:25 p.m. ET (1:25 p.m. Arizona time) and will air on FOX.
The Cardinals have lost three straight games and have allowed over 30 points in all of them. The Lions are 2-2 and coming off a 32-26 loss to the Carolina Panthers.
The Lions are road favorites.
Who will win?
We have dueling expert picks and predictions from yours truly and from the lead writer on our sister site, Lions Wire.
Jess Root, Cards Wire
Well, the Cardinals haven't beaten the Lions since 2015 and have lost nine straight games to Jared Goff, who has 16 touchdown passes and three rushing touchdowns in those nine games. While Detroit's defense is bad, too, they have a pass rush the Cardinals can't
counter, especially down two starting offensive linemen. It is a shootout, but the Lions are in control most of the game. Lions 41, Cardinals 31
Josh Helmer, Lions Wire
Dan Campbell has preached this week that he's not settling for mediocrity. There's clear deficiencies on the Lions' defense that you can only band-aid up so much, but I do anticipate seeing an inspired Detroit team that understands it needs this game before it heads into its bye week. Led by Gibbs and an efficient day from Goff, the Lions pick up their first road victory in 2026. Lions 34, Cardinals 27.
Get more Cardinals and NFL coverage from Cards Wire's Jess Root and others by listening to the latest on the Rise Up, See Red podcast. Subscribe on Spotify, YouTube or Apple Podcasts.
This article originally appeared on Cards Wire: Dueling expert picks for Lions vs. Cardinals in Week 5
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