Cardinals vs. 49ers history: Arizona struggling in recent meetings

The Arizona Cardinals will face the San Francisco 49ers on Sunday on the road. They have not had a ton of recent success against the 49ers. They lost to them in both meetings last season and are 2-6 in their last eight against them. The 49ers lead the all-time series 38-31. The Cardinals had an 8-0

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What is the story about?

The Arizona Cardinals will face the San Francisco 49ers on Sunday on the road. They have not had a ton of recent success against the 49ers. They lost to them in both meetings last season and are 2-6 in their last eight against them.

The 49ers lead the all-time series 38-31.

The Cardinals had an 8-0 run from 2015-2018, but the Niners have won nine of the last 14 meetings since.

49ers starting quarterback Brock Purdy is 5-1 in six starts against the Cardinals in his career. Backup Mac Jones beat them last season. The only other recent win by the Cardinals was a 2024 win when Joshua Dobbs started for the 49ers.

For first-year head coach Mike LaFleur, he gets to coach against his mentor, Kyler Shanahan, for whom he worked as an assistant with the 49ers

from 2017-2020.

The Cardinals have lost three of their last 4 meetings on the road against the 49ers but are 6-5 at Levi's Stadium since it opened in 2014.

Get more Cardinals and NFL coverage from Cards Wire's Jess Root and others by listening to the latest on the Rise Up, See Red podcast. Subscribe on Spotify, YouTube or Apple Podcasts.