The Arizona Cardinals are big underdogs again in Week 3. They are 8-point to 8.5-point underdogs against the San Francisco 49ers on the road, depending on the sportsbook.
After their 31-7 loss to the Seattle Seahawks last week, there isn't a lot of confidence in the Cardinals to beat the 49ers.
In fact, for the third consecutive week, the entire panel of NFL Network experts pick against the Cardinals unanimously.
Here are this week's picks:

Of the 10 analysts, eight expect the 49ers to win by double digits. That is a fair prediction, as the Cardinals are 2-12 with Jacoby Brissett at quarterback with seven defeats of at least 17 points. He is 0-5 against the NFC West with all five losses being by at least 17 points.
In Week 1, the Cardinals upset
the LA Chargers 26-14. Last week, though, everyone was proven right with the Cardinals getting blown out 31-7.
How will the game on Sunday play out?
We will find out starting at 4:05 p.m. ET (1:05 p.m. Arizona time).
Get more Cardinals and NFL coverage from Cards Wire's Jess Root and others by listening to the latest on the Rise Up, See Red podcast. Subscribe on Spotify, YouTube or Apple Podcasts.
This article originally appeared on Cards Wire: Cardinals vs. 49ers picks: Experts unanimous against Cardinals
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