Seahawks vs. Cardinals live updates: Score, highlights, predictions, analysis

The Arizona Cardinals play their home opener on Sunday against the Seattle Seahawks. Both teams are 1-0. The Seahawks are missing starting quarterback Sam Darnold, who is out with a glute injury, which means Drew Lock starts. The Cardinals have lost nine straight games to the Seahawks. They kick off

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What is the story about?

The

Arizona Cardinals play their home opener on Sunday against the Seattle Seahawks. Both teams are 1-0. The Seahawks are missing starting quarterback Sam Darnold, who is out with a glute injury, which means Drew Lock starts.

The Cardinals have lost nine straight games to the Seahawks.

They kick off at 4:25 p.m. ET.

Below is our coverage of the game.

Seahawks vs. Cardinals score

Get more Cardinals and NFL coverage from Cards Wire's Jess Root and others by listening to the latest on the Rise Up, See Red podcast. Subscribe on Spotify, YouTube or Apple Podcasts.

Seahawks at Cardinals predictions, betting odds

12:38 PM ET, September 20 2026, Jess Root

Odds via BetMGM.

Seahawks 24, Cardinals 13. Seattle's defense will be too much for the Cardinals' promising offense, and Arizona's defense will not be prepared for the physical dogfight the Seahawks will bring.
Spread: Seahawks (-4)
Total O/U: 41
Moneyline: Seahawks (-210)