Cardinals vs. Chargers live updates: Score, highlights, predictions, analysis

The NFL regular season is here, and the Arizona Cardinals open their schedule on the road against the Los Angeles Chargers. It will be the regular-season debut for Mike LaFleur as head coach. The Cardinals went 3-14 in 2025 and released quarterback Kyler Murray. They roll with Jacoby Brissett at qua

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What is the story about?

The NFL regular season is here, and the Arizona Cardinals open their schedule on the road against the Los Angeles Chargers. It will be the regular-season debut for Mike LaFleur as head coach. The Cardinals went 3-14 in 2025 and released quarterback Kyler Murray. They roll with Jacoby Brissett at quarterback.

They face a Chargers team that has been to the postseason two years in a row under head coach Jim Harbaugh.

The Chargers are 9.5-point favorites.

Get real-time updates, scoring plays, turning points and expert analysis throughout the Cardinals' game against the Chargers. Follow along for highlights, injury news, key plays and instant breakdown as the Cardinals and Chargers play in Week 1.

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