The Cyclones had a successful run under Matt Campbell, but Iowa State football will move on in 2026 under new head coach Jimmy Rogers. Rogers went 6-6 as head coach at Washington State a year ago and is hoping to prove his chops in the Big 12.
The Cyclones' season starts with a home date against Southeast Missouri State out of the Ohio Valley Conference in FCS. The Redhawks won a 23-21 nail-biter in Week 0 against Indiana State on the road and will have their hands full in a second consecutive contest away from home.
If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.
Southeast Missouri State vs. Iowa State game odds
All college football odds via BetMGM
- Spread: Southeast Missouri State +29.5 (-110), Iowa State -29.5 (-110)
- Money Line: Southeast Missouri State +2500, Iowa State -10000
- Over-Under: Over 53.5 (-110), Under 53.5 (-110)
Southeast Missouri State vs. Iowa State prediction, pick:
Southeast Missouri State received a strong kicking performance
from Justin Keller last week, who made three field goals, including a 45-yarder, to take the lead in the fourth quarter. Chances are, the Redhawks won't be in a position to settle for three points and have a chance to win this week against a Big 12 opponent.
The Cyclones allowed the third-fewest rushing yards of any team in the Big 12 last season, which could be an important note to remember if Rogers' group can perform the way they did under Campbell last season.
The Redhawks didn't turn the ball over last week, but the immense pressure on quarterback Braylen Ragland against Iowa State will likely be too much to overcome if they can't run the football.
Prediction: Iowa State 46, Southeast Missouri State 12
Best Bet: Iowa State -29.5
Southeast Missouri State vs. Iowa State, start time, streaming:
Time: 1 p.m. ET
Live Stream: ESPN+
Watch Southeast Missouri State vs. Iowa State on ESPN+
Get more betting analysis and predictions at Sportsbook Wire.
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This article originally appeared on College Sports Wire: Southeast Missouri St vs. Iowa St: Week 1 Betting Odds, Prediction
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