Week 7 is full of insane football games, including in the ACC. Some matchups are especially exciting, especially in the noon window. The game between the Clemson Tigers and Charleston Southern Buccaneers, meanwhile, is meant to be a tune-up game.
Clemson (3-2) is looking for a tune-up. In Week 5, they lost to the Miami Hurricanes 41-13. They had two straight ACC wins that increased their stock: a comeback victory against UNC and a road win against Cal, but the Miami loss halted their momentum for now. With the bye, they're trying to go through it again.
Charleston Southern (3-3) comes from the Ohio Valley Conference in the Football Championship Subdivision (FCS). They're 3-3 this year, and they've been wildly inconsistent. They lost close to Lindenwood,
and Georgia Southern shut them out, but then they won in overtime against The Citadel and won 65-0 against Point University. After the bye they lost close to Gardner-Webb and won against South Carolina State.
If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.
Charleston Southern vs. Clemson game odds:
All college football odds via BetMGM
- Money Line: N/A
- Over/Under: Over 55.5 (-105), Under 55.5 (-115)
- Spread: Clemson -43.5 (-110), Charleston Southern +43.5 (-110)
Charleston Southern vs. Clemson prediction, pick:
This is a classic FBS vs. FCS tune-up game. Clemson is paying Charleston Southern $450,000 for this game, so the question is whether or not they get their money's worth.
Clemson is going to need to establish the running game again. After two weeks of over 180 yards from the ground game, they ran for just 55 yards in the Miami game. Gideon Davidson needs to go off in this game.
This is a good game for Tait Reynolds. Fresh off the bye, he can get back into rhythm again. This will be a good get-right game for the offensive line as well. I think Clemson wins big.
Score Prediction: Clemson 45, Charleston Southern 3
Best Bet: Under 55.5
Charleston Southern vs. Clemson start time, streaming
Date: Saturday, Oct. 17, 2026
Time: Noon ET
TV: ACC Network
Stream: FuboTV, ESPN
Watch Charleston Southern vs. Clemson on FuboTV (Free Trial)
Get more betting analysis and predictions at Sportsbook Wire.
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This article originally appeared on College Sports Wire: Charleston Southern vs. Clemson: Week 7 Betting Odds, Prediction
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