The Jacksonville Jaguars are down another key player on defense.
Playing against the Indianapolis Colts, the Jaguars lost Eric Murray to an elbow injury early in the game.
Then, during a key defensive play, NT DaVon Hamilton went to the ground, clutching his knee. Colts running back Jonathan Taylor was handed the ball in the backfield, but tripped and lost it; UDFA Bryan Thomas Jr. recovered the ball quickly, and it led to a touchdown for Jacksonville. However, it came with what may be a huge price.
Hamilton went down and had to be taken off the field on a cart. He has since been ruled out with a knee injury, though it's not known yet how serious it is. He was reportedly able to walk to the cart, but while supported by Josh Hines-Allen and Arik
Armstead.
DT DaVon Hamilton has been ruled out of today's game with a knee injury.
— JaguarsPR (@JaguarsPR) November 1, 2026
Hamilton has been a huge contributor to the success of the Jaguars' run defense. He has been one of the best in the league in run-stop rate, though most of his contributions aren't flashy. He excels at clogging running lanes and occupying blockers, and is an anchor for the defense.
If Hamilton has suffered a serious injury, it will strike a major blow to Jacksonville. Arik Armstead, Ruke Orhorhoro, and Matt Dickerson are the Jaguars' remaining defensive tackles.
We will update this article as additional reports come in.
This article originally appeared on Jaguars Wire: Jaguars lose key defender to injury v. Colts in Week 8
