The Cincinnati Bearcats (4-0, 1-0 Big 12) and the Arizona Wildcats (3-1, 0-1) meet Saturday in a Big 12 battle at Casino Del Sol Stadium in Tucson, Arizona. Kickoff is scheduled for 11 p.m. ET (FOX). Let's analyze college football odds around the Cincinnati vs. Arizona odds and make our expert college football picks and predictions for the best bets.
Arizona leads the all-time series 1-0; the Wildcats won 30-24 at Nippert Stadium in Cincinnati, Ohio, on Nov. 15, 2025, as a 5.5-point underdog (+170 ML) in the first-ever meeting as Big 12 conference foes.
Cincinnati stayed unbeaten with a 31-26 victory over Kansas State as a 6.5-point underdog at home last Saturday in the conference opener as the Over (55.5) cashed. Cincinnati is 3-0 against the spread
(ATS) in 3 true home games, and 0-1 ATS in a neutral-site game in Cincinnati at TQL Stadium against Miami (Ohio) on Sept. 19. The Over has cashed in 3 straight outings for the Bearcats.
Arizona stopped Washington State in Pullman last Saturday, 34-24, but it just missed the cover as 11.5-point road favorites. The Wildcats slipped to 0-4 ATS on the season, while the Over has cashed in 2 in a row after the Under cashed in the first 2 outings. The Wildcats lost their only previous game against the Big 12, falling 28-17 at BYU on Sept. 12 as a 6.5-point underdog as the Under (48.5) hit.
– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports
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Cincinnati at Arizona odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 2:15 a.m. ET.
- Moneyline (ML): Cincinnati +205 (bet $100 to win $205) | Arizona -250 (bet $250 to win $100)
- Against the spread (ATS): Cincinnati +7 (-115) | Arizona -7 (-105)
- Over/Under (O/U): 55.5 (O: -112| U: -108)
Cincinnati at Arizona picks and predictions
Prediction
Arizona 31, Cincinnati 27
Moneyline
Arizona (-250) will cost you 2.5 times your potential return, and that's way too much risk for not enough return on a singular play, even with a boost or promo. If you were to throw the Wildcats into a multi-leg parlay, that's perfectly OK, though.
PASS.
Against the spread
CINCINNATI +7 (-115) is worth playing, but it would be even better with 7 and a hook. Arizona is 0-4 ATS and just can't be trusted laying a moderate number against an unbeaten team.
Over/Under
OVER 55.5 (-114) is the lean, but go with a half-unit play at best.
The total has gone high in the past 2 games for the Wildcats, who have averaged 38.0 while giving up 20.5 in those games. The Bearcats have scored at least 31 points in all 4 games and average 33.3 ppg in 3 matchups against FBS opponents. Cincinnati has allowed 28.5 PPG in its past 2 outings, too.
Best prop bet
Arizona QB Noah Fifita - OVER 278.5 PASSING YARDS (-114)
Fifita has thrown for at least 279 passing yards in each of the Wildcats' 3 victories, including 297 yards last week at Washington State. Cincinnati allows 254.0 passing yards per contests, so Fifita has the potential for another top-notch passing performance.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow Daniel Dobish on X at @danieledobish. Follow SportsbookWire on X at SportsBookWire and on Facebook.
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This article originally appeared on Sportsbook Wire: Cincinnati Bearcats at Arizona Wildcats odds, picks and predictions
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