The No. 10 Texas Tech Red Raiders (4-0, 1-0 Big 12) and Colorado Buffaloes (2-2, 0-1) tangle in Saturday Big 12 action in Boulder, Colorado. Opening kickoff at Folsom Field is set for 7:30 p.m. ET (FOX). Let's analyze college football odds around the Texas Tech vs. Colorado odds and make our expert college football picks and predictions for the best bets.
Texas Tech defeated Sam Houston 49-14 (Over 56.5) as a -34.5-point home favorite last Saturday. The Red Raiders overcame 4 turnovers, including 3 interceptions, and broke open a 21-14 halftime game with 28 unanswered second-half points. LB Austin Romaine returned interceptions for touchdowns on consecutive Sam Houston passes as Texas Tech notched its season-high in points and improved to 4-0.
Colorado lost 23-13 (Under 54.5) at Baylor (-8.5) last Saturday. The Buffaloes managed just 3 first-half points before a quarterback change helped produce 10 points after halftime, but their comeback bid fell short. Colorado has dropped 2 straight by a combined 64-20 score after opening the season 2-0.
Colorado leads the all-time series -- which dates to 1962 -- 6-5. The Buffaloes won the most recent meeting 41-27 at Texas Tech in 2024, but Texas Tech won 27-24 on its last trip to Boulder in 2010; that remains the Red Raiders' only victory in 5 visits to Folsom Field.
– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports
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Texas Tech at Colorado odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 9:30 p.m. ET.
- Moneyline (ML): Texas Tech -550 (bet $550 to win $100) | Colorado +425 (bet $100 to win $425)
- Against the spread (ATS): Texas Tech -13.5 (-110) | Colorado +13.5 (-108)
- Over/Under (O/U): 49.5 (O: -110 | U: -108)
Texas Tech at Colorado picks and predictions
Prediction
Texas Tech 34, Colorado 17
Moneyline
No interest at such a steep price. PASS.
Against the spread
Texas Tech is 8-2 ATS in its last 10 road games.
Colorado is benching second-year QB Julian Lewis in favor of Utah transfer Isaac Wilson as the new starting signal caller for this game. Wilson went a pedestrian 12 of 25 after Lewis was 11 of 16 in the loss to Baylor.
Texas Tech owns advantages in yards per rush (4.7 to 3.9) and yards per pass attempt (8.3 to 7.3) and has a monster advantage in points per scoring opportunity. The advanced numbers make the separation even larger. Texas Tech ranks highly in adjusted EPA/play and offensive success rate, while Colorado sits at the bottom 40 in those categories.
TTU's down-to-down efficiency and ability to better create and finish drives stand out. The Raiders have the much stronger opponent-adjusted profile all-around.
BACK THE RED RAIDERS -13.5 (-110).
Over/Under
The Over has cashed in 3 straight TTU games.
Look for weather conducive to scoring along with some input from the big-play and havoc/turnover/short-field departments. Yes, Colorado's offense and QB situation are a drag on the Over scenario, but that may well be a fact mitigated by some Red Raider big-score potential.
This one could get away from the Buffs, who just 2 weeks ago gave up 41 points to Northwestern. These two schools combined for 68 points in their last meeting in November 2024.
TAKE THE OVER 49.5 (-110).
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Texas Tech Red Raiders at Colorado Buffaloes odds, picks and predictions
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