The Arizona Cardinals (1-2) and New York Giants (2-1) meet Sunday in Week 4 in East Rutherford, New Jersey. Kickoff from MetLife Stadium is at 1 p.m. ET (CBS). Let's analyze NFL odds around the Cardinals vs. Giants odds and make our expert NFL picks and predictions for the best bets.
The Cardinals have lost 2 straight games after a season-opening win. Last Sunday, they lost to the San Francisco 49ers 36-30 on the road but covered the 7.5-point spread as underdogs. The Over (48.5) cashed. Jacoby Brissett passed for 280 yards and 2 TDs, and RB Jeremiyah Love had 109 yards from scrimmage and scored a touchdown, but the Cardinals allowed 49ers QB Brock Purdy to throw 4 TD passes.
The Giants lost QB Jaxson Dart and EDGE Brian Burns in consecutive weeks
to season-ending knee injuries, but they beat the Tennessee Titans last Sunday 12-7 as 2.5-point home favorites with the Under (37.5) cashing. K Dominic Zvada kicked 4 field goals, and the defense held the Titans to 162 yards of offense.
The Giants and Cardinals meet for the 130th time. The Giants lead 81-46-2 all-time, but the Cardinals have won 6 of the last 8 meetings. The Giants won their last meeting, in 2023, beating the Cardinals in Arizona 31-28 as 4.5-point favorites with the Over (39.5) cashing.
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Cardinals at Giants odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:10 p.m. ET.
- Moneyline (ML): Cardinals -140 (bet $140 to win $100) | Giants +120 (bet $100 to win $120)
- Against the spread (ATS): Cardinals -2.5 (-110) | Giants +2.5 (-108)
- Over/Under (O/U): 44 (O: -112 | U: -105)
Cardinals at Giants key injuries
Cardinals
- OLB Josh Sweat (groin) questionable
- S Dadrion Taylor-Demerson (back) out
Giants
- QB Jaxson Dart (knee) out for season
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Cardinals at Giants picks and predictions
Prediction
Cardinals 16, Giants 13
Moneyline
This is the first time this season in which the Cardinals are favored. They scored 30 points last weekend for the first time since 2024, but their offensive efficiency hasn't been there. Brissett is averaging only 5.6 yards per pass, and the Cardinals are averaging only 3.9 yards per rushing attempt.
They have allowed over 30 points in consecutive games, but the Giants haven't scored a touchdown since Dart went down.
The Cardinals have not stopped the run the last two games, and the Giants want to run the ball physically with Cam Skattebo and Najee Harris.
Arizona's playmakers will be too much, but it will be ugly.
The Cardinals ML isn't a bad bet, but with only a 2.5-point spread, you will get a little better value betting the spread.
PASS.
Against the spread
The Cardinals are 2-1 ATS this season, as are the Giants.
The Giants' last 9 losses, dating back to last season, have been by at least 3 points.
All the Cardinals' wins since the start of last season have been by more than 2 points.
BET CARDINALS -2.5 (-110).
Over/Under
The Under has cashed in 2 of both teams' 3 games this season. The Under is 4-1 in the teams' last 5 meetings.
The Giants haven't scored a touchdown with Jameis Winston at quarterback.
BET UNDER 44 (-105).
Best prop bet
Giants RB Cam Skattebo OVER 63.5 RUSHING YARDS (-115).
Skattebo has only surpassed 63 yards with the 81 he rushed for in Week 1 against the Dallas Cowboys, but the Cardinals have allowed 92 yards and 75 yards to their opponents' leading rusher in their last 2 games.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Arizona Cardinals at New York Giants odds, picks and predictions
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