The Seattle Mariners (64-70) and the Toronto Blue Jays (65-70) open a 3-game series Friday at Rogers Centre in Toronto, Ontario. First pitch is scheduled for 7:15 p.m. ET (Apple TV). Let's analyze MLB odds around the Mariners vs. Blue Jays odds and make our expert MLB picks and predictions for the best bets.
Season series: Mariners lead 2-1
The Mariners (+120) lost 6-0 Wednesday in the interleague series finale against the Philadelphia Phillies, but they took 2 of 3 to win the series, as the Under cashed in the final 2 outings. Seattle is 7-4 in the past 11 games, and 4-3 in the past 7 road outings. The Over is 7-2 in the past 9 games despite the Under in the final 2 games of the Philadelphia series.
The Blue Jays dropped 2 of 3 against the lowly
Kansas City Royals, and Toronto is 4-6 in the past 10 games, while the Over is 3-1-1 in the past 5 games, and 7-2-1 in the aforementioned 10-game span.
This is a rematch of the 2025 AL Championship Series, won by the Blue Jays in 7 games. Seattle exacted a little revenge July 3-5, taking 2 of 3 from Toronto at T-Mobile Park. All 3 games were shutouts for the winning team, as the Under went 2-1.
The Mariners are just 27-39 on the road, while going 10-15 against the AL East. The Blue Jays are 34-35 at home, while going 11-11 vs. AL West teams.
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Mariners at Blue Jays projected starters
RHP Emerson Hancock vs. RHP Dylan Cease
Hancock (7-7, 3.37 ERA) makes his 25th start. He has a 1.12 WHIP, 2.2 BB/9, 8.4 K/9 in 133 2/3 innings.
- Last start: No-decision, 5 2/3 IP, 3 ER, 8 H, 2 HR, 0 BB, 6 K in 6-5 home win in 10 innings vs. Chicago Cubs last Friday
- 2026 road splits (11 starts): 4-3, 3.51 ERA (59 IP, 23 ER), 1.19 WHIP, 8 HR, 17 BB, 48 K
- Career vs. Blue Jays (2 starts - regular season): 1-1, 1.64 ERA (11 IP, 2 ER), 1.00 WHIP, 3 BB, 9 K, 7.4 K/9
Cease (8-5, 2.37 ERA) makes his 25th start. He has a 1.06 WHIP, 4.0 BB/9, 13.0 K/9 in 144 1/3 innings.
- Last start: Win, 6 2/3 IP, 1 ER, 2 H, 5 BB, 8 K in 4-3 win at New York Yankees Saturday
- Last 7 starts: 2-1, 1.96 ERA (46 IP, 10 ER), 0.91 WHIP, 20 BB, 61 K
- 2026 home splits (13 starts), 1-4, 3.03 ERA (74 1/3 IP, 25 ER), 1.17 WHIP, 6 HR, 34 BB, 112 K
- Career vs. Mariners (3 starts - regular season): 1-0, 2.76 ERA (16 1/3 IP, 5 ER), 1.04 WHIP, 2 HR, 7 BB, 19 K, 10.5 K/9
Mariners at Blue Jays odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:54 p.m. ET.
- Moneyline (ML): Mariners +125 (bet $100 to win $125) | Blue Jays -150 (bet $150 to win $100)
- Run line (RL)/Against the spread (ATS): Mariners +1.5 (-170) | Blue Jays -1.5 (+140)
- Over/Under (O/U): 7 (O: -102 | U: -118)
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Mariners at Blue Jays picks and predictions
Prediction
Mariners 3, Blue Jays 2
Moneyline
The MARINERS (+125) are worth a look on the road as short dogs. They come in with a little momentum after a decent showing against the red-hot Phillies, and they have revenge on their minds after last season's ALCS collapse in Toronto. Cease is great this season, but mostly on the road. How has a Cy Young candidate managed just 1 win all season at home?
Run line/Against the spread
MARINERS +1.5 (-170) is not priced out of line if you need some insurance, can't play Seattle straight up.
Seattle is 6-5 on the run line in the past 11 times as an underdog, and it has won 6 times outright. Really, if you like the Mariners, you should back them on the moneyline, but no one can blame you if you need a little cushion.
Over/Under
The UNDER 7 (-118) is a low number, but worth the play with this pitching matchup.
The Under cashed in the final 2 games for the M's against the Phils earlier this week, while the Under is 3-2-1 in the past 6 home games for Toronto. Don't get carried away, but lean low.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Seattle Mariners at Toronto Blue Jays odds, picks and predictions
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