The Boston Red Sox (73-60) and New York Yankees (75-58) open a 4-game AL East series Friday in New York, New York. First pitch from Yankee Stadium is at 7:15 p.m. ET (Apple TV). Let's analyze MLB odds around the Red Sox vs. Yankees odds and make our expert MLB picks and predictions for the best bets.
Season series: Red Sox lead 5-4
The Red Sox are in third place in the AL East, 6 games behind the division-leading Tampa Bay Rays. They are the second Wild Card and trail the Yankees for the top spot by 2 games. They had a 4-game winning streak snapped Wednesday, losing the series finale at the Miami Marlins 4-0 as -130 favorites with the Under (7.5) cashing. They managed only 5 hits and committed 4 errors.
The Yankees have won 7 of their last 10,
but lost 2 out of 3 games at home to the Houston Astros. They lost the finale Thursday 5-1 as -154 favorites with the Under (7.5) cashing, mustering only 5 hits. SP Gerrit Cole allowed 3 runs in 6 innings, taking the loss.
The Red Sox and Yankees will play a doubleheader Saturday because their June 6 was rained out.
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Red Sox at Yankees projected starters
LHP Patrick Sandoval vs. RHP Cam Schlitter
Sandoval (1-2, 4.54 ERA) makes his ninth start. He has a 1.77 WHIP, 4.1 BB/9 and 9.3 K/9 in 39 2/3 innings.
- Last start: No-decision, 5 2/3 IP, 2 ER, 5 H, 2 BB, 6 K in 3-2 home win over San Francisco Giants Saturday
- Career vs. Yankees: 2-2, 3.70 ERA (24 1/3 IP, 10 ER), 1.03 WHIP, 9.6 K/9 in 4 starts
- 2026 road splits: 0-2, 5.59 ERA (19 1/3 IP, 12 ER), 1.86 WHIP, 10.2 K/9 in 4 starts
Schlitter (11-6, 2.16 ERA) makes his 28th start. He has a 0.96 WHIP, 2.1 BB/9 and 11.0 K/9 in 158 innings.
- Last start: Win , 6 IP, 1 ER, 6 H, 3 BB, 4 K in 3-1 home win over Toronto Blue Jays last Friday
- Last start vs. Red Sox (June 7): No-decision, 5 2/3 IP, 1 ER, 4 H, 1 BB, 5 K in 6-1 home win
- Career vs. Red Sox: 1-1, 0.96 ERA (18 2/3 IP, 2 ER), 0.91 WHIP, 9.2 K/9 in 3 starts
- 2026 home splits: 3-4, 3.71 ERA (63 IP, 26 ER), 1.25 WHIP, 11.3 K/9 in 12 starts
Red Sox at Yankees odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:17 a.m. ET.
- Moneyline (ML): Red Sox +135 (bet $100 to win $135) | Yankees -165 (bet $165 to win $100)
- Run line (RL)/Against the spread (ATS): Red Sox +1.5 (-160) | Yankees -1.5 (+135)
- Over/Under (O/U): 7 (O: -118 | U: -102)
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Red Sox at Yankees picks and predictions
Prediction
Red Sox 5, Yankees 4
Moneyline
The Red Sox have beaten the Yankees in 4 straight meetings and in 5 of their last 6. They have been better on the road (39-28) than at home (34-32), while the Yankees are only 34-30 at home.
Boston is 6-2 in Sandoval's 8 starts, while the Yankees are 1-4 in Schlitter's last 5 outings.
BET RED SOX (+135).
Run line/Against the spread
Boston is 13-7 ATS as away underdogs, with 12 of those 13 covers being outright wins. Their last 45 covers have been outright wins.
The Yankees are 25-31 ATS as home favorites.
With plus odds on the ML for the Red Sox to win outright, that is the smarter bet.
PASS.
Over/Under
Five of Sandoval's last 7 starts have had totals of 8 or more. Seven of the Red Sox's last 10 have had totals of 8 or more. While the total in their last games was 4, they have gone 15 games without 2 consecutive games with totals of 7 or less.
Three of the last 4 for the Yankees have had totals above 7.
BET OVER 7 (-118).
Best prop bet
Patrick Sandoval 6+ strikeouts (-115)
Sandoval has had at least 6 Ks in 2 straight starts and in 3 of his last 5.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Boston Red Sox at New York Yankees odds, picks and predictions
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