The Jacksonville Jaguars (1-0) and Denver Broncos (0-1) battle at Empower Field at Mile High in Denver, Colorado. Kickoff is scheduled for 4:05 p.m. ET (CBS). Let's analyze NFL odds around the Jaguars vs. Broncos odds and make our expert NFL picks and predictions for the best bets.
QB Trevor Lawrence threw 4 TD passes as the Jaguars (-8.5) cruised to a 34-10 (Over 40.5) victory vs. the Cleveland Browns in their home opener last Sunday. Lawrence completed 18 of 23 passes for 245 yards and TD passes to WR Parker Washington, WR Jakobi Meyers, WR Josh Cameron and TE Brenton Strange. Washington led all receivers with 5 catches for 83 yards. Jags second-year RB Bhayshul Tuten led all rushers with 15 carries for 66 yards. The Jaguars held the Browns to 272
totals yards (185 passing, 87 rushing) and forced 2 turnovers (1 fumble, 1 interception).
The visiting Broncos were roasted by the Kansas City Chiefs (-1.5) 31-10 (Under 42.5) in their season opener on Monday Night Football. While it marked Chiefs QB Patrick Mahomes' first game since blowing out his knee last December, it was RB Kenneth Walker III who stole the night, gashing the Broncos defense for 173 yards on 23 carries and 1 TD, while also catching 3 passes for 18 yards and another TD. The Broncos offense was completely stifled, totaling 176 yards. Denver QB Bo Nix completed 17 of 28 passes for 131 yards, 1 TD, 1 INT, lost 1 fumble and was sacked 4 times. RB J.K. Dobbins led the Broncos in rushing with 36 yards on 8 carries.
The all-time series is tied 8-8, with the Jaguars winning the most recent meeting last season 34-20 in Denver on Dec. 21, 2025. Lawrence was 23 of 36 for 279 yards and 3 TDs and also ran for 20 yards and a score. Washington caught 6 passes for 145 yards and 1 TD. Nix completed 28 of 47 passes for 352 yards, 1 TD and 1 INT in the loss.
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Jaguars at Broncos odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1:50 p.m. ET.
- Moneyline (ML): Jaguars +125 (bet $100 to win $125) | Broncos -150 (bet $150 to win $100)
- Against the spread (ATS): Jaguars +2.5 (-105) | Broncos -2.5 (-125)
- Over/Under (O/U): 45.5 (O: -108 | U: -110)
Jaguars at Broncos key injuries
JAGUARS
None
BRONCOS
- RB RJ Harvey (hamstring) Questionable
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Jaguars at Broncos picks and predictions
Prediction
Jaguars 31, Broncos 17
Moneyline
BET JAGUARS (+125).
The Jaguars went into Denver last season and handed the Broncos 1 of their 3 losses in relatively easy fashion. After the results of Week 1, is there any question about whether they can do it again?
Now, to be fair, the Jaguars played at home against a team that is likely to be one of the worst in the league, while the Broncos were on the road against a perennial Super Bowl contender.
Nevertheless, the Week 1 results, coupled with last year's result, leave me quite confident about the Jaguars' chances in Denver on Sunday.
Against the spread
PASS.
I typically won't take the points unless I'm getting at least 3 as it doesn't add much value unless you're expecting a tight game, which I'm not, so I'd rather have the plus-money of the moneyline since I'm on the Jags. If you like Denver, note that 3 of their wins last season came by 2 or fewer points, so be mindful if giving the points.
Over/Under
BET OVER 45.5 (-108).
If the game ends up being close, I expect it to be of the high-scoring variety rather than a defensive struggle.
Best prop bet
BET TREVOR LAWRENCE OVER 1.5 PASSING TDS (+135 BETMGM).
Dating back to last season, including playoffs, Lawrence has thrown at least 2 TDs in 8 of his past 9 games. If you're really feeling frisky and can find an ALT line of Over 2.5 Passing TDs, he's thrown at least 3 TDs in 5 of his past 6 games, including playoffs.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Jacksonville Jaguars at Denver Broncos odds, picks and predictions
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