The Indianapolis Colts (0-1) and Kansas City Chiefs (1-0) play on Sunday Night Football in Kansas City, Missouri, in Week 2. Kickoff from Arrowhead Stadium is at 8:20 p.m. ET (NBC). Let's analyze NFL prop bet odds around the Colts vs. Chiefs and tab the 5 best prop bets to go along with SportsbookWire's expert NFL picks and predictions for Week 2.
The Colts were blown out in Week 1, losing 41-23 at home to the Baltimore Ravens as 2.5-point underdogs with the Over (47.5) cashing. Baltimore had 506 yards of offense, while the Colts had only 251 yards. RB Jonathan Taylor scored 2 TDs, but the Colts defense allowed 4 rushing TDs.
The Chiefs opened the season on Monday Night Football, beating the Denver Broncos 31-10 as 2.5-point home favorites with
the Under (42.5) cashing. QB Patrick Mahomes threw 2 TD passes and rushed for another, and RB Ken Walker III rushed for 173 yards and a touchdown in his Chiefs debut.
Watch the NFL on Fubo!
Best Colts vs. Chiefs prop bets
Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Last updated at 10:32 a.m. ET.
Colts K Spencer Shrader OVER 1.5 field goals made (+100)
Shrader made only 1 field goal in Week 1. He only played in 5 games in 2025, but he made multiple field goals in 4 of those games. He made multiple field goals in 2 of his 4 games played in 2024.
SNF: Odds, picks and predictions
Chiefs QB Patrick Mahomes OVER 17.5 rushing yards (-111)
Mahomes rushed for 23 and a TD in the season opener. And while with quarterbacks, you always run the risk of having their rushing total go backwards because of game-ending or half-ending kneel downs, Mahomes had over 17 rushing yards in 9 of 14 games last season.
USA TODAY Sports Fantasy: Sync your ESPN, Yahoo, CBS or Sleeper league in seconds to unlock custom roster advice, expert projections, and start/sit recommendations built for your team. Stop guessing and start winning. Sync your league now!
Chiefs RB Ken Walker III OVER 82.5 rushing yards (-115)
Walker rushed for 173 yards in his debut with the Chiefs. He is the Chiefs' clear No. 1 running back. Dating back to last season and post season, he has rushed for over 82 yards in 5 of his last 7 games.
Chiefs TE Travis Kelce ANYTIME TD (+180)
Kelce didn't score in Week 1. He has, though, scored 2 TDs in 4 career games against the Colts.
Chiefs WR Rashee Rice OVER 51.5 receiving yards (-115)
Rice only had 2 catches for 19 yards in the Chiefs' win over the Broncos. But the Colts allowed Ravens WR Zay Flowers to catch 5 passes for 150 yards last week. In 1 career game against the Colts. Rice has 8 catches for 141 yards.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow SportsbookWire on X at SportsBookWire and on Facebook.
Access more NFL coverage:
USA TODAY Sports Fantasy | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire | High schools
This article originally appeared on Sportsbook Wire: Indianapolis Colts at Kansas City Chiefs best prop bets for Sunday Night Football
Advertiser disclosure: USA TODAY may earn a commission when you sign up through links on this page. Commissions never influence our editorial coverage or rankings. Offers and odds were accurate at publication and are subject to change; terms apply — see the operator’s site. This is general information, not betting, legal or financial advice. To the fullest extent permitted by law, USA TODAY is not liable for losses arising from your use of it.
Must be 21+ (18+ where permitted). Sports betting and casino gaming are not legal everywhere; complying with the laws where you are located is your responsibility. Gamble only with funds you can afford to lose. Gambling problem? Help is available 24/7 — call or text 1-800-GAMBLER, or call the National Problem Gambling Helpline at 1-800-MY-RESET. State helplines and responsible gaming resources.
