The Charlotte Hornets (3-1) and Detroit Pistons (3-1) meet Wednesday for the first of their 4 matchups in the 2026-27 season. Tip from Little Caesars Arena in Detroit, Michigan, is set for 7 p.m. ET. Let's analyze NBA odds around the Hornets vs. Pistons odds and make our expert NBA picks and predictions for the best bets.
2025-26 season series: Pistons won 3-0
The Hornets edged the Washington Wizards 110-103 Monday, covering as a 2.5-point home favorite with the Under (226.5) cashing. They were led by F Brandon Miller, who dropped 39 points on 15 of 28 shooting. Charlotte has won 2 straight, covering in both. Its lone loss of the season was a 47-point beatdown by the Atlanta Hawks Sunday. The Hornets are 3-1 against the spread (ATS) and 0-4 Over/Under
(O/U).
The Pistons lost to the New York Knicks 111-97 Tuesday, failing to cover as a 4.5-point road underdog with the Under (220.5) hitting. F Paul Reed scored a team-high 22 points on 9 of 12 shooting. G Cade Cunningham had 19 points, 9 rebounds and 8 assists. Detroit's Tuesday loss means there are no more undefeated teams in the Eastern Conference. Detroit is 3-1 ATS.
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Hornets at Pistons odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated 9:52 a.m. ET.
- Moneyline (ML): Hornets +230 (bet $100 to win $230) | Pistons -295 (bet $295 to win $100)
- Against the spread (ATS): Hornets +7.5 (-105) | Pistons -7.5 (-115)
- Over/Under (O/U): 214.5 (O: -110 | U: -118)
Hornets at Pistons key injuries
Hornets
- F Kon Knueppel (hamstring) out
- G Coby White (calf) out
- F Grant Williams (hamstring) out
Pistons
(Not yet submitted -- below was for Tuesday's game)
- C Jalen Duren (hamstring) out
- F Ausar Thompson (ankle) questionable
For most recent updates: Official NBA injury report.
Hornets at Pistons picks and predictions
Prediction
Pistons 116, Hornets 106
Moneyline
PASS.
Avoid this play. The Pistons (-295) should win, but they are too expensive to consider on the moneyline.
Against the spread
BET PISTONS -7.5 (-115).
By trading G LaMelo Ball and F Miles Bridges, the Hornets have allowed a space for Miller to take over as their primary weapon, and he's averaging 36.5 points per game across the last 2 contests. However, the Pistons have yet to allow more than 113 points in a game and have the size to make life challenging on the star forward.
Without White or Knueppel to add offensive firepower, the Hornets' offense should struggle. Detroit has covered both games as a favorite and is 1-0 ATS at home as well. In each of its victories, it has won by at least 8 points. Expect those trends to continue and back PISTONS -7.5 (-115).
Over/Under
BET OVER 214.5 (-110).
Both offenses have consistently produced this season, and that's the key coming into Wednesday's matchup.
The Hornets have scored at least 110 points in 3 of their 4 games and tallied 110 in their lone road contest. Detroit has slowed down offensively, but is 2-2 O/U and put up 121 points in its only home game this season. Back OVER 214.5 (-110).
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This article originally appeared on Sportsbook Wire: Charlotte Hornets at Detroit Pistons odds, picks and predictions
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