The St. Louis Cardinals (72-72) and San Francisco Giants (59-85) open a 3-game series on Monday in San Francisco, California. First pitch from Oracle Park is at 8:10 p.m.m ET (NBC / Peacock). Let's analyze MLB odds around the Cardinals vs. Giants odds and make our expert MLB picks and predictions for the best bets.
2025 season series: Cardinals won 4-2
The Cardinals are 4 games out of the final Wild Card. They have won 6 out of their last 10 games and are coming off series win over the Colorado Rockies on the road, winning 2 out of 3. They closed out the series Sunday with a 10-8 win as -136 favorites with the Over (11) cashing. They fell behind 5-0 and then erupted for a 6-run fifth inning. DH Ivan Herrera had 3 hits, 2 runs and 2 RBIs, while
1B Alec Burleson added 3 hits, a run and drove in 1.
The Giants return home after a 3-4 road trip, but they lost 3 of their last 4. They lost their series finale 4-2 Sunday to the New York Mets as +130 underdogs with the Under (8) cashing. They took a 2-0 lead into the eighth inning, but RP Carson Seymour allowed a 3-run homer to 3B Bo Bichette and a solo shot by DH-1B Brett Baty.
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Cardinals at Giants projected starters
RHP Michael McGreevy vs. RHP Logan Webb
McGreevy (6-9, 3.97 ERA) makes his 28th start. He has a 1.26 WHIP, 2.4 BB/9 and 6.2 K/9 in 147 1/3 innings.
- Last start: Win, 5 IP, 4 ER, 5 H, 2 BB, 4 K in 13-8 win at Los Angeles Dodgers Tuesday
- Career vs. Giants: 2-1, 6.35 ERA (17 IP, 12 ER), 1.41 WHIP, 5.8 K/9 in 3 starts
- 2026 road splits: 4-5, 3.89 ERA (76 1/3 IP, 33 ER), 1.18 WHIP, 6.7 K/9 in 14 starts
Webb (8-8, 4.21 ERA) makes his 26th start. He has a 1.16 WHIP, 2.3 BB/9 and 7.2 K/9 in 149 2/3 innings.
- Last start: No-decision, 2 IP, 9 ER, 9 H, 2 BB, 1 K in 13-12 loss at Pittsburgh Pirates Tuesday
- Career vs. Cardinals: 3-3, 5.19 ERA (43 1/3 IP, 25 ER), 1.57 WHIP, 7.9 K/9 in 8 starts
- 2026 home splits: 4-4, 3.39 ERA (85 IP, 32 ER), 1.00 WHIP, 6.8 K/9 in 13 starts
Cardinals at Giants odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:13 p.m. ET.
- Moneyline (ML): Cardinals +110 (bet $100 to win $110) | Giants -135 (bet $135 to win $100)
- Run line (RL)/Against the spread (ATS): Cardinals +1.5 (-190) | Giants -1.5 (+155)
- Over/Under (O/U): 7.5 (O: -118 | U: -102)
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Cardinals at Giants picks and predictions
Prediction
Cardinals 6, Giants 5
Moneyline
The Cardinals are 38-34 on the road and are 4-2 on their current road trip. The Giants are 33-36 at home and 32-50 against teams with at least a .500 record.
The Giants are 9-16 in Webb's starts and have lost his last 5 outings. The Cardinals have won 5 of McGreevy's last 6 starts.
BET CARDINALS (+110).
Run line/Against the spread
Five of the Cardinals' last 7 covers have been outright losses. Ten of the Giants' last 14 losses have been ATS losses as well.
With plus odds on the Cardinals ML, that is your better bet.
PASS.
Over/Under
McGreevy's last 9 starts have had totals above 7. So have Webb's last 4 and 8 of his last 11.
Eight of the Giants' last 10 games and 15 of the Cardinals' last 17 games have had totals of 8 or more.
BET OVER 7.5 (-118).
Best prop bet
Michael McGreevy OVER 3.5 strikeouts (+115)
McGreevy has had 4 or more strikeouts in 5 of his last 6 starts. He has had 4 or more in 14 of his 27 starts.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: St. Louis Cardinals at San Francisco Giants odds, picks and predictions
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