The Philadelphia 76ers (3-1) visit the Indiana Pacers (2-2) Wednesday at Gainbridge Fieldhouse in Indianapolis, Indiana. Tip-off is for a 7 p.m. ET (ESPN). Let's analyze NBA odds around the 76ers vs. Pacers odds and make our expert NBA picks and predictions for the best bets.
2025-26 season series: 76ers won 4-0
Philadelphia dropped its first game of the season Sunday, a 106-93 (Under 227.5) loss to the Detroit Pistons as a 1.5-point home underdog. G Tyrese Maxey scored a game-high 29 points, while F LeBron James added 18 and G Jaylen Brown had 16. They were the only 76ers players to score in double figures.
Indiana lost 102-100 at the Milwaukee Bucks Monday, failing to cover as a 3.5-point favorite with the Under (239.5) hitting. G Tyrese Halibruton
led the team with 22 points and 9 assists, while F Pascal Siakam added a double-double (20 points, 13 rebounds).
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76ers at Pacers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:45 p.m. ET.
- Moneyline (ML): 76ers -175 (bet $175 to win $100) | Pacers +145 (bet $100 to win $145)
- Against the spread (ATS): 76ers -4.5 (-110) | Pacers +4.5 (-110)
- Over/Under (O/U): 237.5 (O: -105 | U: -115)
76ers at Pacers key injuries
76ers
- F Dominick Barlow (back) out
- C Tacko Fall (quadriceps) out
- F Jabari Walker (knee) out
Pacers
- G Tyrese Haliburton (hamstring) questionable
- G T.J. McConnell (hamstring) out
- G Andrew Nembhard (neck) questionable
- G Aaron Nesmith (hamstring) probable
- F Obi Toppin (hand) probable
- C Ivica Zubac (ankle) out
For most recent updates: Official NBA injury report.
76ers at Pacers picks and predictions
Prediction
76ers 121, Pacers 113
Moneyline
PASS.
There is minimal value on the 76ers (-175) to win Wednesday.
Against the spread
BET 76ERS -4.5 (-110).
The Pacers are simply banged up and dealing with many different absenses. With a majority of the team questionable, including Haliburton, it will be exceedingly important to keep an eye on the injury report prior to this matchup.
The Sixers have looked dominant so far this season, winning by at least 6 points in each of their 3 wins, while covering in 2 of their 4 games. They have many options available to get past the Pacers, even on the road.
Over/Under
BET UNDER 237.5 (-115).
While this game could have the makings of a high energy scoring fest later in the season, both teams are still getting their groove and finding their rhythm. The Sixers have hit the Under in 3 of their 4 games, scoring 114 or fewer in each of the games in which they hit the Under, while allowing 106 or fewer in each of those games as well.
The Pacers have hit the Under in 2 of their last 3, including their only home game this season. They have scored 105 or fewer in 2 of their last 3, while allowing 110 or fewer in back-to-back contests.
Best prop bet
BET ALTERNATE TEAM TOTALS: PACERS UNDER 117.5 (-125 on DraftKings Sportsbook).
The Pacers have scored 117 or fewer in 2 of their last 3, scoring just 105 or fewer in both games. They are dealing with a number of nagging injuries to crucial players that will alter their flow. Unless they have the hot hand at home, this will be smooth sailing.
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This article originally appeared on Sportsbook Wire: Philadelphia 76ers at Indiana Pacers odds, picks and predictions
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