The Chicago Cubs (81-63) and Milwaukee Brewers (88-56) meet Monday to commence a 3-game NL Central series. First pitch from American Family Field in Milwaukee, Wisconsin, is set for 2:10 p.m. ET. Let's analyze MLB odds around the Cubs vs. Brewers odds and make our expert MLB picks and predictions for the best bets.
Season series: Brewers lead 6-4
The Cubs lost to the Miami Marlins 10-3 Sunday, failing to cover as a -142 moneyline favorite with the Over (8) cashing. Chicago had its 3-game winning streak snapped with the loss, and despite that streak, it is just 5-7 over its last 12 games. The Cubs sit second in the NL Central and are atop the NL Wild Card race, 1/2-game ahead of the Philadelphia Phillies and 5 games ahead of the third-place Arizona
Diamondbacks.
The Brewers, who lead the NL Central by 7 games over the Cubs and have the best record in the NL, lost to the Cincinnati Reds 12-8 Sunday. They closed as a -149 moneyline favorite with the Over (8.5) clearing with ease. Milwaukee has dropped 3 of its last 4 games and is 3-3 in September. Its offense has been on a run, tallying at least 8 runs in 4 of its last 6 outings.
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Cubs at Brewers projected starters
LHP Matthew Boyd vs. LHP Robert Gasser
Boyd (8-3, 4.05 ERA) makes his 19th start. He has a 1.23 WHIP, 2.7 BB/9 and 6.9 K/9 in 102 1/3 innings.
- Last start: No-decision, 5 1/3 IP, 3 ER, 7 H, 1 BB, 3 K in a 9-4 home loss vs. Brewers Tuesday
- Career vs. Brewers: 2-2, 8.26 ERA (28 1/3 IP, 26 ER), 1.91 WHIP, 7.0 K/9 in 6 starts
- 2026 road splits: 3-1, 2.83 ERA (54 IP, 17 ER), 1.24 WHIP, 4 HR, 21 BB, 38 K in 9 starts
Gasser (4-5, 4.57 ERA) makes his 17th start (18th appearance). He has a 1.29 WHIP, 2.8 BB/9 and 8.5 K/9 in 86 2/3 innings.
- Last start: No-decision, 4 1/3 IP, 2 ER, 3 H, 2 BB, 4 K in a 9-4 victory at Cubs Tuesday
- Career vs. Cubs: 0-0, 1.74 ERA (10 1/3 IP, 2 ER), 0.77 WHIP, 9.6 K/9 in 2 starts
- 2026 home splits: 1-2, 4.05 ERA (40 IP, 18 ER), 1.28 WHIP, 4 HR, 14 BB, 35 K in 8 starts
Cubs at Brewers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 11:14 p.m. ET.
- Moneyline (ML): Cubs +105 (bet $100 to win $105) | Brewers -130 (bet $130 to win $100)
- Run line (RL)/Against the spread (ATS): Cubs +1.5 (-200) | Brewers -1.5 (+165)
- Over/Under (O/U): 8.5 (O: -105 | U: -115)
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Cubs at Brewers picks and predictions
Prediction
Brewers 5, Cubs 4
Moneyline
BET BREWERS (-130).
Milwaukee has been the fifth-best team in the majors after a loss at 32-23, and it is 75-45 as a favorite as well. The Brewers have won 2 of 3 games in their last 4 3-game home series, so there's a good chance they're able to take this one at home.
The Cubs have also struggled defensively over the last week. They have allowed at least 9 runs in 3 of their last 6 games. Chicago is just 2-3 in its past 5 road performances.
Run line/Against the spread
PASS.
Avoid this play. The Cubs +1.5 (-200) are too expensive as a road underdog and the Brewers -1.5 (+165) are too risky as a home favorite.
Over/Under
BET OVER 8.5 (-105).
Both sides have significant Over trends coming into this one.
The Cubs have gone Over in 2 straight games and in 8 of their previous 10 outings. They have scored 15 runs in their last 3 games. Similarly, the Brewers are 6-2 O/U in their past 8 performances and have put up 21 runs across their last 3 games.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Chicago Cubs at Milwaukee Brewers odds, picks and predictions
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