The Los Angeles Chargers (0-2) visit the Buffalo Bills (2-0) Sunday for a 1 p.m. ET (FOX) kickoff from Highmark Stadium in Orchard Park, New York. Let's analyze NFL odds around the Chargers vs. Bills odds and make our expert NFL picks and predictions for the best bets.
Los Angeles remains winless after losing 26-14 for the second consecutive week, this time against the Las Vegas Raiders, failing to cover as a 6.5-point home favorite with the Under (43.5) hitting. QB Justin Herbert threw for 192 yards with a touchdown and 2 interceptions, while RB Omarion Hampton ran for 94 yards and a TD. The Chargers fumbled the ball 6 times, failing to recover only a single one, in the losing effort.
Buffalo is still undefeated after taking down the Detroit
Lions 41-31 last Thursday, covering as a 4.5-point home favorite with the Over (55.5) cashing. QB Josh Allen threw for 248 yards with 3 TDs, while adding 69 yards rushing and 2 TDs on the ground. In total, the Bills rushed for 203 yards and 3 TDs in the dominant victory.
Watch the NFL on Fubo!
Chargers at Bills odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:40 p.m. ET.
- Moneyline (ML): Chargers +275 (bet $100 to win $275) | Bills -350 (bet $350 to win $100)
- Against the spread (ATS): Chargers +7 (-108) | Bills -7 (-110)
- Over/Under (O/U): 50 (O: -108 | U: -110)
Chargers at Bills key injuries
Chargers
- TE Charlie Kolar (forearm) out
- S Elijah Molden (hamstring) questionable
- T Trey Pipkins (knee) out
- WR Brenen Thompson (quadricep) out
- DT Dalvin Tomlinson (hamstring) out
Bills
- WR Keon Coleman (ankle) questionable
- CB Jordan Hancock (hamstring) out
- WR DJ Moore (shoulder) questionable
- DT Ed Oliver (hip) questionable
- G Ar'maj Reed-Adams (elbow) questionable
- DE T.J. Sanders (illness) out
USA TODAY Sports Fantasy: Sync your ESPN, Yahoo, CBS or Sleeper league in seconds to unlock custom roster advice, expert projections, and start/sit recommendations built for your team. Stop guessing and start winning. Sync your league now!
Chargers at Bills picks and predictions
Prediction
Bills 38, Chargers 24
Moneyline
PASS.
There is no value on the Bills (-350) moneyline.
Against the spread
BET BILLS -7 (-110).
The Bills and Chargers are trending in opposite directions, with the Chargers being 0-2 both straight up (SU) and against the spread (ATS) and the Bills being 2-0 both SU and ATS.
The Chargers were favored in both games and lost each by 12 points, with their offense, led by Herbert, struggling to move the ball and the defense struggling to get much-needed stops. Both fronts will have an increasingly difficult time against the Bills, who have already looked like a top team in the league.
The Bills' offense has been a force, putting up 77 points through their first two games, and they should be the reason the team cruises to 3-0 both SU and ATS on Sunday.
Over/Under
BET OVER 50 (-108).
The Bills have scored at least 36 points in each of their games this season, easily hitting the Over in each game. They have also allowed 31 points in both games, opening an opportunity for Herbert to gain some momentum.
The Chargers have allowed 26 points in both games, against two teams much worse overall than Allen and the Bills. While they have only scored 14 points in both games, this should be an offensive showing from both sides.
Best prop bet
BET JOSH ALLEN RUSHING YARDS: 35+ (-115 on DraftKings Sportsbook).
Through 2 games, Allen has 20 rushing attempts and 92 yards, with 2 TDs on the ground in each matchup. While he shouldn't be expected to continue to pound in TDs on the ground every week, he has demonstrated an ability to escape the pocket and make plays with his feet, something that may be a necessity with a banged-up WR room.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow SportsbookWire on X at SportsBookWire and on Facebook.
Access more NFL coverage:
USA TODAY Sports Fantasy | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire | High schools
This article originally appeared on Sportsbook Wire: Los Angeles Chargers at Buffalo Bills odds, picks and predictions
Advertiser disclosure: USA TODAY may earn a commission when you sign up through links on this page. Commissions never influence our editorial coverage or rankings. Offers and odds were accurate at publication and are subject to change; terms apply — see the operator’s site. This is general information, not betting, legal or financial advice. To the fullest extent permitted by law, USA TODAY is not liable for losses arising from your use of it.
Must be 21+ (18+ where permitted). Sports betting and casino gaming are not legal everywhere; complying with the laws where you are located is your responsibility. Gamble only with funds you can afford to lose. Gambling problem? Help is available 24/7 — call or text 1-800-GAMBLER, or call the National Problem Gambling Helpline at 1-800-MY-RESET. State helplines and responsible gaming resources.
