The New York Yankees (78-60) and Los Angeles Angels (53-85) play the second game of their 3-game series in Anaheim, California, on Tuesday. First pitch from Angel Stadium is at 9:38 p.m. ET. Let's analyze MLB odds around the Yankees vs. Angels odds and make our expert MLB picks and predictions for the best bets.
Season series: Angels lead 3-2
The Yankees are 5-5 in their last 10 games and lost the opener 10-1 Monday as -122 favorites with the Over (7.5) cashing. Their only run was a solo home run from RF Spencer Jones. SP Elmer Rodriguez Cruz (3 2/3 IP, 4 ER, 4 H, 3 BB, 5 K) fell to 0-3.
The Angels were +112 underdogs in the win, snapping a 7-game losing streak. They pounded out 12 hits, and 1B Vaughn Grissom went 3 for 5 with 2 runs and 4 RBIs.
SP Walbert Urena (7 IP, 1 ER, 5 H, 0 BB, 8 K) evened his record at 9-9.
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Yankees at Angels projected starters
RHP Gerrit Cole vs. RHP Grayson Rodriguez
Cole (7-7, 3.19 ERA) makes his 18th start. He has a 1.07 WHIP, 1.9 BB/9 and 9.6 K/9 in 98 2/3 innings.
- Last start: Loss, 6 IP, 3 ER, 6 H, 1 BB, 5 K in 5-1 home loss to Houston Astros Thursday
- Career vs. Angels: 8-2, 2.48 ERA (76 1/3 IP, 21 ER), 0.96 WHIP, 12.1 K/9 in 12 starts
- 2026 road splits: 4-4, 3.04 ERA (50 1/3 IP, 17 ER), 1.23 WHIP, 9.8 K/9 in 9 starts
Rodriguez (4-5, 6.03 ERA) makes his 16th start. He has a 1..52 WHIP, 3.9 BB/9 and 8.2 K/9 in 71 2/3 innings.
- Last start: No-decision, 5 2/3 IP, 1 ER, 7 H, 1 BB, 4 K in 4-3 home loss to Cleveland Guardians Wednesday
- Career vs. Yankees: 1-1, 3.18 ERA (17 IP, 6 ER), 1.29 WHIP, 7.4 K/9 in 3 starts
- 2026 home splits: 1-3, 7.78 ERA (39 1/3 IP, 34 ER), 1.81 WHIP, 8.5 K/9 in 9 starts
Yankees at Angels odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:15 a.m. ET.
- Moneyline (ML): Yankees -190 (bet $190 to win $100) | Angels +154 (bet $100 to win $154)
- Run line (RL)/Against the spread (ATS): Yankees -1.5 (-110) | Angels +1.5 (-110)
- Over/Under (O/U): 7.5 (O: -115 | U: -105)
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Yankees at Angels picks and predictions
Prediction
Yankees 6, Angels 3
Moneyline
The Yankees have not lost consecutive games over their last 15 contests. Their 41-29 road record is the second-best in all of baseball. They are 4-2 in Cole's last 6 starts.
The Angels have not won consecutive games over their last 16. They are 1-7 in Rodriguez's last 8 starts, 30-42 at home and 24-48 against teams with at least a .500 record. Don't expect them to win again.
The Yankees win, but the run line gives you better odds betting either team.
PASS.
Run line/Against the spread
Fifteen of the Angels' last 19 losses have been by 2 or more runs. Seven of their 11 losses when Rodriguez pitches have been by 2 or more runs.
Ten of the Yankees' last 12 wins have been by 2 or more runs.
BET YANKEES -1.5 (-110).
Over/Under
All 5 meetings this season have had totals of 8 or more. Six of the Yankees' last 9 games have had totals of 8 or more.
Five of Cole's last 6 starts have not reached 8 total runs, but 5 of Rodriguez's last 7 have.
BET OVER 7.5 (-115).
Best prop bet
Gerrit Cole OVER 6.5 strikeouts (-110)
Cole has struck out 7 or more in 5 of his last 8 starts, and he has alternated between 7 or more and 5 or fewer in 6 straight outings. He struck out 5 in his last start.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: New York Yankees at Los Angeles Angels odds, picks and predictions
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