The Tampa Bay Buccaneers (1-5) and the Carolina Panthers (3-2) meet Sunday for a Week 7 matchup at Bank of America Stadium in Charlotte, North Carolina. Kickoff is scheduled for 1 p.m. ET (FOX). Let's analyze NFL odds around the Buccaneers vs. Panthers odds and make our expert NFL picks and predictions for the best bets.
These NFC South Division combatants split their season series in 2025, with the home team winning each game. Carolina won 23-20 on Dec. 21 as a 3-point underdog as the Under (44.5) cashed. The total went low in both meetings in 2025, after the Over was 2-0 in 2024. The Buccaneers have won 6 of the past 7 meetings in this series since Jan. 1, 2023, but the Panthers are 3-1 against the spread (ATS) in the past 4 in the series,
while holding a slight 5-3 ATS edge in the previous 8 meetings.
Tampa Bay (+2.5) lost a heartbreaker 26-19 in overtime to the Pittsburgh Steelers in Week 6. The Over (37.5) cashed, halting a 3-game Under run. The Buccaneers are 1-5 ATS in the first 6 games, while their only win and cover came on the road in Week 5 in a Thursday night 24-16 win at the Dallas Cowboys.
Buccaneers QB Baker Mayfield (thumb) was able to practice in full all week, as he makes his way back from a dislocated right thumb. He carries a questionable tag into the game, meaning he is, essentially, 50-50. He'll be without top receiver WR Emeka Egbuka (concussion, foot), as he has been ruled out.
Carolina (-2.5) went on the road and beat a banged-up Philadelphia Eagles team 25-14 as the Under (39.5) hung on. The Panthers have won consecutive games, sandwiching a bye in Week 5. They're also 2-0 ATS in the past 2 games, with the Under going 3-1 in the previous 4 outings.
SUNDAY NIGHT FOOTBALL: Best prop bets
Buccaneers at Panthers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 8:21 p.m. ET.
- Moneyline (ML): Buccaneers +130 (bet $100 to win $130) | Panthers -160 (bet $160 to win $100)
- Against the spread (ATS): Buccaneers +3 (-118) | Panthers -3 (-102)
- Over/Under (O/U): 44.5 (O: -110 | U: -108)
Buccaneers at Panthers injuries
Buccaneers
- WR Emeka Egbuka (concussion, foot) out
- OT Luke Goedeke (calf) out
- QB Baker Mayfield (thumb) questionable
- S Antoine Winfield Jr. (rib) out
Panthers
- OT Monroe Freeling (knee) questionable
- LB Thomas Incoom (calf) out
- LB Bam Martin-Scott (hamstring) questionable
- LB Jaelan Phillips (hamstring) out
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Buccaneers at Panthers picks and predictions
Prediction
Panthers 23, Buccaneers 18
Moneyline
The PANTHERS (-160) are worth a play as moderate favorites straight up, if you're a bit conservative, and you just want to pick a winner.
With Mayfield, potentially back, that's good news for the Buccaneers. But, Tampa Bay's top receiver, Egbuka, is out, so that should hamper the offense, even if the Bake Show is able to go.
Against the spread
The PANTHERS -3 (-102) are worth playing, especially at this price, despite their struggles over the years with the Buccaneers. Tampa Bay has really had difficult this season, and if Mayfield can play, we don't know if there will be any rust. But, it doesn't help that the second-year receiver Egbuka isn't available to him.
Over/Under
UNDER 44.5 (-108) is worth a look, as both teams have cashed the Under at a 3-1 clip in the past 4 outings. We could get a lot more field goals than touchdown in this one in Charlotte.
Best prop bet
Buccaneers QB BAKER MAYFIELD - OVER 0.5 INTERCEPTIONS (-115 at BetMGM)
Mayfield is likely to have some rust after a multiple week layoff. Going on the road, facing a good defense, it's likely that Mayfield has at least one miscue in the passing game.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow Daniel Dobish on X at @danieledobish. Follow SportsbookWire on X at SportsBookWire and on Facebook.
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This article originally appeared on Sportsbook Wire: Tampa Bay Buccaneers at Carolina Panthers odds, picks and predictions
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