The Minnesota Twins (73-83) and San Francisco Giants (64-92) open a 3-game series in San Francisco, California, on Monday. First pitch from Oracle Park is at 9:45 p.m. ET. Let's analyze MLB odds around the Twins vs. GIants odds and make our expert MLB picks and predictions for the best bets.
Season series: First meeting; Twins went 3-0 against Giants in 2025.
The Twins are 5-9 in their last 14 games and have been eliminated from postseason contention. The went 2-2 in their series on the road against the Los Angeles Angels over the weekend, winning the finale on Sunday 8-0 as -111 favorites with a push (8) for the total. Dean Kremer allowed 1 hit in 6 innings and Alan Roden had 3 hits and 4 RBIs, including his first homer of the year.
The Giants
are also out of contention. They have lost 3 in a row and 7 of their last 9. They lost the finale against the Dodgers in Los Angeles 3-1 on Sunday as +229 underdogs with the Under (8.5) cashing. They scored in the top of the first but didn't cross the plate again.
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Twins at Giants projected starters
RHP Zebby Matthews vs. RHP Blade Tidwell
Matthews (9-10, 4.74 ERA) makes his 23rd start. He has a 1.25 WHIP, 2.8 BB/9 and 7.7 K/9 through 125 1/3 innings.
- Last start: No-decision, 6 IP, 0 ER, 2 H, 2 BB, 8 K in 5-4 13-inning home win over the New York Yankees on Wednesday
- Facing Giants for the first time in his career
- 2026 road splits: 4-6, 6.93 ERA (62 1/3 IP, 48 ER), 1.43 WHIP, 9.2 K/9 in 12 starts
Tidwell (1-2, 4.56 ERA) makes his ninth start and 17th appearance. He has a 1.20 WHIP, 3.5 BB/9 and 7.1 K/9 through 53 1/3 innings.
- Last start: Win, 6 2/3 IP, 2 ER, 3 H, 1 BB, 4 K in 10-3 road win over St. Louis Cardinals on Tuesday
- Facing Twins for first time
- 2026 home splits: 0-1, 5.88 ERA (26 IP 17 ER), 1.27 WHIP, 6,6 K/9 in 8 games (4 starts)
Twins at Giants odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:55 p.m. ET.
- Moneyline (ML): Twins -120 (bet $120 to win $100) | Giants +100 (bet $100 to win $100)
- Run line (RL)/Against the spread (ATS): Twins -1.5 (+135) | Giants +1.5 (-165)
- Over/Under (O/U): 8.5 (O: +100 | U: -120)
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Twins at Giants picks and predictions
Prediction
Giants 5, Twins 4
Moneyline
The Twins are only 33-45 on the road this season and Matthews' ERA is almost 7.00 in away games. They are 5-13 in their last 18 away games.
The Giants are 36-39 at home and 7-6 in their last 13 home games. They have won Tidwell's last 2 outings.
BET GIANTS (+100).
Run line/Against the spread
The Giants are 31-26 ATS as home underdogs but 11 of their last 15 covers have been outright wins.
The Twins' last 23 ATS losses have been outright losses.
You are better off betting the ML on the Giants.
PASS.
Over/Under
Eight of the Giants' last 10 games have had totals of 9 or more. Six of the Twins' last 8 games also have had totals of 9 or more. The Over is 6-1-1 in the Twins' last 8 games and is 8-2 in the Giants' last 10.
BET OVER 8.5 (+100).
Best prop bet
Zebby Matthews UNDER 4.5 strikeouts (-120)
He has had 5 or more strikeouts in 3 of his last 5 outings, but he has had no more than 4 in 8 of his last 12 starts.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Minnesota Twins at San Francisco Giants odds, picks and predictions
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