The No. 5 Indiana Hoosiers (5-0, 2-0 Big Ten) and Nebraska Cornhuskers (5-0, 2-0) meet Saturday for a Week 6 Big Ten clash. Kickoff from Memorial Stadium in Lincoln, Nebraska, is set for noon ET. Let's analyze college football odds around the Indiana vs. Nebraska odds and make our expert college football picks and predictions for the best bets.
Indiana throttled the Rutgers Scarlet Knights 47-15 Saturday, covering as a 24.5-point road favorite with the Over (55.5) cashing. QB Josh Hoover hit 20 of 27 passes for 251 yards and 4 TDs. Hoover has passed for 1,101 yards with 15 TDs and 0 INTs. The Hoosiers, who have been a favorite of more than 20 points in each of their games this season, are just 1-4 against the spread (ATS). They've relied heavily
on their rock-solid defense, which has held 2 of their 5 opponents scoreless, and allows only 10.8 points per game (PPG), fifth-best in the nation. Indiana has tallied at least 29 points in all 5 games and is 3-2 O/U.
Nebraska has yet to lose a game as well, having won each of its 5 contests by at least 18 points. The Cornhuskers beat the Maryland Terrapins 48-23 Saturday, covering as a 15.5-point home favorite as the Over (52.5) hit. Nebraska has been dominant on both sides of the ball, having yet to allow more than 23 points in a game and just 14.2 PPG (17th of 138), while scoring at least 31 points in all 5 outings and averaging 43.5 PPG (10th). It is 4-1 ATS and 3-2 O/U. Dual-threat QB Anthony Colandrea has 1,142 passing yards with 13 TDs and 2 INTs, and has rushed for 249 yards and 2 scores.
Indiana leads the all-time 11-9-3, including a 56-7 win in the last meeting in 2024.
– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports
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Indiana at Nebraska odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 1:27 a.m. ET.
- Moneyline (ML): Indiana -285 (bet $285 to win $100) | Nebraska +225 (bet $100 to win $225)
- Against the spread (ATS): Indiana -7.5 (-105) | Nebraska +7.5 (-115)
- Over/Under (O/U): 48.5 (O: -105 | U: -115)
Indiana at Nebraska picks and predictions
Prediction
Indiana 28, Nebraska 24
Moneyline
PASS.
Avoid this play. Expect Indiana (-285) to get the job done on the road, but things certainly won't be a walk in the park for the reigning national champs.
Against the spread
BET NEBRASKA +7.5 (-115).
Love or hate him, Matt Rhule is one of the most experienced collegiate coaches and has helped the Cornhuskers improve in each of his 4 seasons. They've gone from 5-7 in 2023 to 7-6 in 2024-25 and should be even better this season. Nebraska has made its home field a fortress, outscoring opponents 187 to 78. It is 3-1 ATS at home as well as being 6-4-1 ATS at home since the start of the 2025 season.
The Hoosiers haven't lived up to expectations so far this season, and they haven't been challenged either. Indiana has played just 1 road game and is 1-1 ATS in conference action. Its defense has allowed 19 points per game across its Big Ten contests (5.7 in non-conference games) and will get its toughest test yet this season Saturday.
Expect a close battle and back NEBRASKA +7.5 (-115).
Over/Under
BET OVER 48.5 (-110).
So far this season, one constant for these teams is that both offenses know how to score. Indiana has averaged 38 points per game in conference play and is 2-0 O/U in those contests. home.
Nebraska is averaging 39.5 PPG across its 2 Big Ten outings. It has 4 players on its roster with at least 195 rushing yards, so it should be able to wear down a stout Indiana defensive line. The Cornhuskers are 3-1 O/U at home.
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This article originally appeared on Sportsbook Wire: Indiana Hoosiers at Nebraska Cornhuskers odds, picks and predictions
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