The Pittsburgh Steelers (3-2) and Tampa Bay Buccaneers (1-4) square off in Week 6 at Raymond James Stadium in Tampa, Florida, on Sunday. Kickoff is scheduled for 1 p.m. ET (CBS). Let's analyze NFL odds around the Steelers vs. Buccaneers odds and make our expert NFL picks and predictions for the best bets.
Despite different starts to their seasons so far, the Steelers and Buccaneers both head into this one riding similar highs.
Pittsburgh bounced back from a disheartening loss to the Cleveland Browns and answered the bell last weekend against the Indianapolis Colts. Led by RB Jaylen Warren's two long touchdown plays, the Steelers beat the Colts, 34-22. QB Aaron Rodgers turned the clock back as well with 235 passing yards and three touchdowns. TE
Pat Freiermuth caught two of them with Warren grabbing the other.
The Bucs' high heading into Week 6 is clear: Tampa got its first win of the season against the Dallas Cowboys on Oct. 8. With QB Baker Mayfield (thumb) out, UDFA backup QB Jalon Daniels led the Buccaneers to that first victory of season in a 24-16 fashion. However, it was more so the RB Bucky Irving show. The Tampa running back had 165 yards on the ground and two total touchdowns in the win. A strong defensive effort once again now has the Bucs sitting as the No. 7 overall defense in the NFL, allowing 299.4 yards per game.
The Steelers lead this all-time series, 10-2, as these cross-conference foes have not played since 2022. That was a 20-18 win for Pittsburgh. In 2026, the Steelers mirror their record against the spread and against the point totals, going 3-2 in both categories. Likewise, the Bucs are 1-4 ATS like their overall record but have hit the Over twice. However, the Under has hit in three straight games for Tampa Bay.
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Steelers at Buccaneers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 7:50 p.m. ET.
- Moneyline (ML): Steelers -145 (bet $145 to win $100) | Buccaneers +120 (bet $100 to win $120)
- Against the spread (ATS): Steelers -2.5 (-115) | Buccaneers +2.5 (-105)
- Over/Under (O/U): 39 (O: -108 | U: -110)
Steelers at Buccaneers key injuries
Steelers
- DT Keeanu Benton (ankle) questionable
- CB Jamel Dean (ankle) questionable
- RB Rico Dowdle (toe) questionable
- S DeShon Elliott (knee) out
- CB Jalen Ramsey (wrist) questionable
- WR Ben Skowronek (calf) out
- WR Roman Wilson (injured reserve, finger) out
Buccaneers
- LB SirVocea Dennis (ankle/foot) questionable
- CB Ayden Garnes (ankle) questionable
- QB Baker Mayfield (thumb) out
- CB Benjamin Morrison (quad) doubtful
- WR Davis Sills V (hamstring) out
- LB Josiah Trotter (knee) questionable
- RB Sean Tucker (quad) questionable
- S Antonie Winfield Jr. (rib) out
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Browns at Jets picks and predictions
Prediction
Steelers 20, Buccaneers 13
Moneyline
PASS.
While the Steelers are the pick here, there is more value in taking the spread, which is under a field goal with Pittsburgh on the road.
Against the spread
BET STEELERS -2.5 (-115).
With such a close spread, earn a little more by going with the Steelers. While Pittsburgh has some worries at wide receiver in terms of health, the Steelers showed they can get it done offensively in other ways. The Bucs do have a formidable defense, but as enticing as a home underdog is, their offense got it done last time against a brutal Cowboys defense. The Steelers will be another story.
Over/Under
BET UNDER 39 (-110).
It's a low number for a good reason and the formula is pretty clear. The Bucs have a strong defense that won't allow the Steelers to run wild on them. Sometimes facing a backup quarterback can be blown out of proportion, but Daniels is still just an undrafted rookie under center. It's hard to imagine a lot of points going up in this one.
BEST PROP BET
BET JAYLEN WARREN ANYTIME TD (-110)
Warren is the hot hand after last week. Keep rolling with him to get in the end zone again as he has some pretty decent odds here for being the go-to rusher for the Steelers.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Pittsburgh Steelers at Tampa Bay Buccaneers odds, picks and predictions
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