The Detroit Pistons (2-0) visit the Philadelphia 76ers (3-0) Sunday. Tip-off from Wells Fargo Center in Philadelphia, Pennsylvania, is set for 7:30 p.m. ET. Let's analyze NBA odds around the Pistons vs. 76ers odds and make our expert NBA picks and predictions for the best bets.
2025-26 season series: Pistons won 4-0, including in NBA Cup
Detroit routed the Miami Heat 128-111 Friday to cover as a 2.5-point road favorite as the Over (235.5) hit. The Pistons held the Heat to just 39 of 102 (38%) shooting from the field and 15 of 51 (29%) from long range while winning the rebounding battle for the second consecutive game. The Pistons grab 51 rebounds per game, good for fourth in the NBA. F John Collins led Detroit with 23 points, 1 of 6 Pistons scoring
in double figures.
Philadelphia continued its hot start to the season with a 127-116 win over the Milwaukee Bucks Saturday while covering as a 12.5-point home favorite as the Over (234.5) cashed. C Joel Embiid dropped a triple-double with 28 points, 11 rebounds, and 10 assists, while G Tyrese Maxey scored 26 and F Jaylen Brown finished with 27. F LeBron James sat out the first night of a back-to-back, but he is expected to play here, while Embiid is expected to be out for rest in this matchup.
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Pistons at 76ers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:53 a.m. ET.
- Moneyline (ML): Pistons -115 (bet $115 to win $100) | 76ers -105 (bet $105 to win $100)
- Against the spread (ATS): Pistons -1.5 (-102) | 76ers +1.5 (-118)
- Over/Under (O/U): 227.5 (O: -110 | U: -110)
Pistons at 76ers key injuries
Pistons
- C Jalen Duren (hamstring) out
- F Ausar Thompson (ankle) questionable
76ers
(Not yet submitted -- below was for Saturday's game)
- F Dominick Barlow (back) out
- C Tacko Fall (quad) out
- C Ariel Hukporti (achilles) out
For most recent updates: Official NBA injury report.
Pistons at 76ers picks and predictions
Prediction
76ers 117, Pistons 114
Moneyline
BET 76ERS (-110).
With Duren out, the probable resting of Embiid should be much more bearable for Philly. Also, the return of F Dean Wade will likely be huge for the defense of the Sixers in this matchup, especially if Embiid is out and another bigger body is needed in the starting lineup. Detroit's defense is still elite, but the Pistons won't be able to get enough going offensively to win this game, and when Detroit has multiple shooters in the game at once, expect that Philly gets whatever it wants on offense.
Against the spread
PASS.
The Sixers will cover here as +1.5 (-118) underdogs, but expecting a Philadelphia win the ML is a better value.
Over/Under
LEAN OVER 227.5 (-110).
Both centers likely being out for this matchup means that both teams will be a bit weaker on the glass and a bit weaker defensively in the paint, and I could also see it leading to both teams trying to play faster and get out in transition more. Both teams still have great perimeter defenders, but I expect this to be a game where we get big numbers from the stars that lead to the Over cashing.
The Over is 2-0 for the Pistons this season.
Best prop bet
76ers F LEBRON JAMES OVER 6.5 REBOUNDS (-155).
LeBron is averaging 9.5 rebounds per game this season, and with Embiid out, the responsibility to crash the glass will fall heavily on his shoulders, and the opportunity will be there. Also, if the Sixers are going to get out in transition consistently in this game, LeBron is the guy you want taking the rebound and either making the outlet pass or just taking the ball up the court.
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This article originally appeared on Sportsbook Wire: Detroit Pistons at Philadelphia 76ers odds, picks and predictions
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