The San Francisco 49ers (7-1) and Dallas Cowboys (4-5) meet Sunday in Foxborough, Massachusetts, for a Week 10 battle. Kickoff from Arlington, Texas is at 4:25 p.m. ET (FOX). Let's analyze NFL odds around the 49ers vs. Cowboys odds and make our expert NFL picks and predictions for the best bets.
The 49ers bounced back from their first loss of the season with a convincing 38-17 victory over the Las Vegas Raiders in Week 9. San Francisco covered as an 8.5-point home favorite as the Over (51.5) hit. The defense forced 4 turnovers, including a LB Jaden Dugger pick-6. QB Brock Purdy threw 2 TDs and rushed for another, while RB Christian McCaffrey added a rushing and receiving score.
The Cowboys picked up a much-needed victory in Week 9, edging the
Indianapolis Colts 27-23. Dallas failed to cover as a 4.5-point road favorite as the Under (51.5) hit. QB Dak Prescott threw for 335 yards and 3 TDs, connecting with WR CeeDee Lamb 10 times for 195 yards and a score. RB Javonte Williams added 101 rushing yards and a TD.
The 49ers have won and covered 4 straight meetings with Dallas, including a 30-24 victory Oct. 27, 2024. San Francisco covered as a 5.5-point home favorite with the Over (47.5) cashing.
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49ers at Cowboys odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:28 p.m. ET.
- Moneyline (ML): 49ers -220 (bet $220 to win $100) | Cowboys +180 (bet $100 to win $190)
- Against the spread (ATS): 49ers -4 (-110) | Cowboys +4 (-108)
- Over/Under (O/U): 56 (O: -110 | U: -110)
49ers at Cowboys injuries
49ers
- WR Mike Evans (Achilles) out
- CB Renardo Green (back) questionable
- LB Dre Greenlaw (knee) questionable
- CB Nate Hobbs (groin) questionable
- CB Deommodore Lenoir (foot) questionable
- CB Upton Stout (shoulder, neck) questionable
- DT C.J. West (knee) questionable
- OT Trent Williams (shoulder) questionable
Cowboys
- CB DaRon Bland (ankle) questionable
- DT Jonathan Bullard (calf) questionable
- S Alijah Clark (illness) questionable
- LB Donovan Ezeiruaku (ankle) out
- TE Jake Ferguson (knee, ankle) out
- RB Tyler Goodson (ankle, knee) out
- S P.J. Locke (concussion) out
- WR Jonathan Mingo (ankle) out
- CB Devin Moore (hip) questionable
- CB Joey Porter Jr. (ankle, foot) questionable
- S Juanyeh Thomas (hamstring) doubtful
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49ers at Cowboys picks and predictions
Prediction
49ers 34, Cowboys 24
Moneyline
PASS.
The 49ers (-220) are just a far superior team on both sides of the ball. I like them to win, but there is no value in betting the moneyline, I'll take my wager to the spread.
Against the spread
BET 49ERS -4 (-110).
San Francisco's offense has been rolling, averaging 29.4 points per game, and Dallas' defense hasn't exactly been stopping anybody. The Cowboys are allowing 26.2 points and nearly 400 yards per contest, which could spell trouble against Purdy and company.
McCaffrey should have plenty of room to work against a Dallas defense surrendering 147.4 rushing yards per game. The 49ers are also converting an impressive 84.6% of their red-zone trips into touchdowns.
Defensively, San Francisco is allowing just 81 rushing yards per game, which could leave Prescott doing most of the heavy lifting. The 49ers are fresh off a 38-17 win over Las Vegas and have won and covered 4 straight meetings with Dallas. That's a pretty favorable matchup for San Francisco.
Over/Under
BET OVER 56 (-110).
Both offenses can light up the scoreboard, and neither defense inspires much confidence. San Francisco leads the NFL in offensive EPA per play, while Dallas ranks seventh and averages 27.3 points per game. The Cowboys have allowed at least 20 points in every game, and injuries in the 49ers' secondary could give Prescott plenty of opportunities to air it out. This one has shootout written all over it.
Best prop bet
49ers WR JORDAN WATKINS OVER 22.5 RECEIVING YARDS (-116) on DraftKings).
Injuries to San Francisco's receiving corps have forced Watkins into a bigger role, and he's made the most of it. Watkins is averaging 22.4 yards per catch and is coming off a career-best performance against Las Vegas, hauling in 4 passes for 86 yards and a TD. He's topped 55 receiving yards in 3 of 4 games in which he's been targeted. Dallas has allowed 28 completions of at least 20 yards, so 1 big catch could do the trick.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: San Francisco 49ers at Dallas Cowboys odds, picks and predictions
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