The Detroit Tigers (72-81) and Chicago White Sox (78-75) play the second game of their 4-game AL Central series in Chicago, Illinois, Friday. First pitch from Rate Field is at 7:40 p.m. ET. Let's analyze MLB odds around the Tigers vs. White Sox odds and make our expert MLB picks and predictions for the best bets.
Season series: White Sox lead 7-3
The Tigers, who are 6 games out of the final Wild Card with 9 games left in the regular season, have lost 2 straight after a 6-game winning streak. They lost the series opener Thursday 3-1 as -104 underdogs with the Under (8.5) cashing. SP Framber Valdez struck out 8 in 5 innings, but allowed a first-inning 3-run home run to 1B Munetaka Murakami.
The White Sox are tied for the AL Central lead with the Cleveland
Guardians. They have lost 7 of their last 10 games, but stopped a 2-game skid with their win Thursday as -116 favorites. Murakami's homer was enough to win the game, as 4 relievers combined to allow just 1 run on 8 hits and strike out 10.
Watch MLB on Fubo!
Tigers at White Sox projected starters
LHP Andrew Sears vs. RHP David Sandlin
Sears (0-1, 5.40 ERA) makes his third start and fifth career appearance. The 24-year-old rookie has a 1.38 WHIP, 4 BB and 13 K in 16 2/3 innings.
- Last start: No-decision, 4 1/3 IP, 4 ER, 7 H, 1 BB, 5 K in 11-7 home win over Colorado Rockies Saturday
- Facing White Sox for first time
- 2026 road splits: 0-1, 5.59 ERA (9 2/3 IP, 6 ER), 1.35 WHIP. 6.5 K/9 in 2 games (1 start)
Sandlin (2-2, 5.64 ERA) makes his fifth start and seventh career appearance. The 25-year-old rookie has a 1.19 WHIP, 3.6 BB/9 and 8.6 K/9 in 30 1/3 innings.
- Last start: Loss, 5 2 /3 IP, 0 ER (3 R), 2 H, 0 BB, 5 K in 3-1 loss at St. Louis Cardinals Sunday
- Facing Tigers for first time
- 2026 home splits: 2-0, 4.15 ERA (17 1/3 IP, 8 ER), 0.92 WHIP, 7.3 K/9 in 3 games (2 starts)
Tigers at White Sox odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:24 a.m. ET.
- Moneyline (ML): Tigers +110 (bet $100 to win $110) | White Sox -135 (bet $135 to win $100)
- Run line (RL)/Against the spread (ATS): Tigers +1.5 (-190) | White Sox -1.5 (+155)
- Over/Under (O/U): 8.5 (O: -110 | U: -110)
Slide into: BaseballHQ.com for your fantasy baseball news. For decades, BHQ has been helping players just like you win! BHQ offers full-season subscriptions. Sign up today!
Tiger at White Sox picks and predictions
Prediction
White Sox 6, Tigers 4
Moneyline
The White Sox are 4-0 at home against the Tigers this season and have won their last 4 meetings this year. Yes, the Tigers had a 6-game winning streak, but all 6 of those wins came over sub-.500 teams.
The White Sox are 44-31 at home, while the Tigers are 33-45 on the road and 27-43 against teams with at least a .500 record.
BET WHITE SOX (-135).
Run line/Against the spread
The Tigers are 23-12 ATS as road underdogs, and the White Sox are 9-13 ATS as home favorites. But 4 of the 7 wins the White Sox have over the Tigers have been by 2 or more runs.
Ten of the Tigers' last 15 losses have been by 2 or more runs. Eleven of the last 14 wins for the White Sox have been by 2 or more runs.
BET WHITE SOX -1.5 (+155).
Over/Under
Seven of the 10 meetings this season have not reached 9 total runs. The Tigers' last 5 losses have had totals below 9, but 5 of the last 7 for the White Sox and 6 of the last 10 for the Tigers have had totals of 9 or more.
BET OVER 8.5 (-110).
Best prop bet
David Sandlin 5+ strikeouts (+120)
Sandlin has struck out 5 or more batters in 3 of his last 4 appearances.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow SportsbookWire on X at SportsBookWire and on Facebook.
This article originally appeared on Sportsbook Wire: Detroit Tigers at Chicago White Sox odds, picks and predictions
Advertiser disclosure: USA TODAY may earn a commission when you sign up through links on this page. Commissions never influence our editorial coverage or rankings. Offers and odds were accurate at publication and are subject to change; terms apply — see the operator’s site. This is general information, not betting, legal or financial advice. To the fullest extent permitted by law, USA TODAY is not liable for losses arising from your use of it.
Must be 21+ (18+ where permitted). Sports betting and casino gaming are not legal everywhere; complying with the laws where you are located is your responsibility. Gamble only with funds you can afford to lose. Gambling problem? Help is available 24/7 — call or text 1-800-GAMBLER, or call the National Problem Gambling Helpline at 1-800-MY-RESET. State helplines and responsible gaming resources.
