The Boston Red Sox (87-75) clash with the New York Yankees (93-68) Tuesday in Game 1 of their AL Wild Card series in New York, New York. First pitch at Yankee Stadium is 8 p.m. ET (NBC). Let's analyze MLB odds around the Red Sox vs. Yankees odds and make our expert MLB picks and predictions for the best bets.
Season series: Yankees won 7-6
Boston's 2-game winning streak was snapped in Sunday's regular-season finale, a 6-2 to the Chicago Cubs as a -101 home favorite with the Over (7.5) hitting. C Adley Rutschman had a solo shot, while the Red Sox went 0 for 7 with runners in scoring position. Boston finished third in the AL East, 11 games behind the Tampa Bay Rays. It finished second in the AL Wild Card race with a 3-game cushion over the Chicago White
Sox.
New York won its final game of the season Friday, 6-3 over Baltimore Orioles 6-3 as a -115 home favorite with the Over (6.5) hitting. Five Yankees had a RBI and SS Anthony Volpe led the way with 2 RBIs. New York finished second in the AL East, 4.5 games behind the Rays. It finished atop the AL Wild Card standings 6 1/2 games ahead of Boston.
Watch MLB on Fubo!
Red Sox at Yankees projected starters
LHP Payton Tolle vs. RHP Cam Schlittler
Tolle (9-6, 3.03 ERA) makes his 27th start. He has a 1.10 WHIP, 2.4 BB/9 and 10.4 K/9 in 148 2/3 innings.
- Last start: No-decision, 5 2/3 IP, 2 ER, 8 H, 2 BB, 5 K in a 3-2 home loss vs. Cleveland Guardians Tuesday
- Career vs. Yankees: 1-0, 0.69 ERA (13 IP, 1 ER), 0.54 WHIP, 12.5 K/9 in 2 starts
- 2026 road stats: 6-3, 2.50 ERA (72 IP, 20 ER), 0.97 WHIP, 52 H, 6 HR, 18 B, 70 K in 12 starts
Schlittler (14-6, 1.95 ERA) makes his 34th start. He has a 0.92 WHIP, 2.3 BB/9 and 11.1 K/9 in 193 2/3 innings.
- Last start: No-decision, 3 IP, 1 ER, 3 H, 2 BB, 5 K in a 6-4 home victory vs. Tampa Bay Rays Thursday
- Career vs. Red Sox: 2-1, 0.74 ERA (24 1/3 IP, 2 ER), 0.99 WHIP, 10.0 K/9 in 4 starts
- 2026 home stats: 6-4, 2.98 ERA (84 2/3 IP, 28 ER), 1.14 WHIP, 71 H, 8 HR, 26 B, 110 K 16 starts
Red Sox at Yankees odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:23 a.m. ET.
- Moneyline (ML): Red Sox +120 (bet $100 to win $120) | Yankees -140 (bet $140 to win $100)
- Run line (RL)/Against the spread (ATS): Red Sox +1.5 (-185) | Yankees -1.5 (+155)
- Over/Under (O/U): 6.5 (O: -102 | U: -118)
Slide into: BaseballHQ.com for your fantasy baseball news. For decades, BHQ has been helping players just like you win! BHQ offers full-season subscriptions. Sign up today!
Red Sox at Yankees picks and predictions
Prediction
Yankees 4, Red Sox 2
Moneyline
BET YANKEES (-140).
With home-field advantage and Schlittler on the mound, the advantage lies with the Pinstripes. The Yankees finished 46-34 at home, while Schlittler was one of the league's top pitchers, with top-5 ranks in ERA (1.95; second), strikeouts (239, T-third), and WHIP (0.92, fourth). The second-year pitcher takes the mound with confidence, while his offense, which has scored 6 or more runs in 3 of their last 4 games, provides as much support as he will need.
Run line/Against the spread
PASS.
While there is some value on the Yankees -1.5 (+155), the safest play in this historic matchup is the moneyline.
Over/Under
BET UNDER 6.5 (-120).
Both Schlittler and Tolle have had a lot of success in baseball's greatest rivalry, with the pitchers combining for 3 ER in 37 1/3 innings. Expect both pitchers to take the spotlight for a captivating Game 1.
The Red Sox have hit the Under in 8 of their last 10 games. They have scored 2 or fewer runs in 7 of their last 8, while allowing 3 or fewer in 8 of their last 10.
The Yankees have scored 4 or fewer in 6 of their last 10, while allowing 4 or fewer in 4 of their last 6.
Best prop bet
Yankees CAM SCHLITTLER 8+ STRIKEOUTS (+118, DraftKings Sportsbook)
This bet presents an opportunity for profit for Schlitter, who is primed for a great outing. He is coming off a 5-strikeout outing in which he only pitched 3 innings and struck out at least 8 in 4 of his last 5 games before that. The Sox bats have not been performing well, which is the cherry on top.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow SportsbookWire on X at SportsBookWire and on Facebook.
This article originally appeared on Sportsbook Wire: Boston Red Sox at New York Yankees odds, picks and predictions
Advertiser disclosure: USA TODAY may earn a commission when you sign up through links on this page. Commissions never influence our editorial coverage or rankings. Offers and odds were accurate at publication and are subject to change; terms apply — see the operator’s site. This is general information, not betting, legal or financial advice. To the fullest extent permitted by law, USA TODAY is not liable for losses arising from your use of it.
Must be 21+ (18+ where permitted). Sports betting and casino gaming are not legal everywhere; complying with the laws where you are located is your responsibility. Gamble only with funds you can afford to lose. Gambling problem? Help is available 24/7 — call or text 1-800-GAMBLER, or call the National Problem Gambling Helpline at 1-800-MY-RESET. State helplines and responsible gaming resources.
