The Los Angeles Dodgers (97-62) and the San Francisco Giants (65-94) open a 3-game NL West series Friday at Oracle Park in San Francisco, California. First pitch is scheduled for 10:15 p.m. ET. Let's analyze MLB odds around the Dodgers vs. Giants odds and make our expert MLB picks and predictions for the best bets.
Season series: Dodgers lead 6-4
The Dodgers suffered a 4-2 loss Friday against the San Diego Padres while cashing the Under (7.5). L.A. slipped 3 games behind the Milwaukee Brewers (100-65) for the top spot in the National League with 3 games to play. L.A. has scored 3 total runs in the past 2 games after a 5-game win streak, and the Under has cashed in 4 consecutive outings.
The Giants lost 2 of 3 games against the Minnesota Twins prior
to this series, and San Francisco has dropped 5 of the past 6 games, and 9 of the past 12 outings. The Under has cashed in 4 in a row, too. San Francisco has long since been eliminated from the postseason chase.
San Francisco will face LHP Tarik Skubal, and it is just 19-29 against left-handed starting pitchers and 17-32 inside the division. L.A. is 30-19 against NL West opponents.
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Dodgers at Giants projected starters
LHP Tarik Skubal vs. RHP Yunior Marte
Skubal (11-7, 2.85 ERA with Detroit Tigers and Dodgers) makes his 26th start. He has a 0.99 WHIP, 1.6 BB/9, 10.4 K/9 in 151 2/3 innings.
- Last start: Win, 5 IP, 4 ER, 8 H, 1 HR, 2 BB, 3 K in 10-4 home victory vs. Giants Saturday
- Last 7 starts: 4-1, 2.66 ERA (44 IP, 13 ER), 1.14 WHIP, 9 BB, 48 K
- 2026 road splits (11 starts): 5-4, 1.87 ERA (67 1/3 IP, 14 ER), 0.83 WHIP, 5 HR, 8 BB, 77 K
- Career vs. Giants (3 starts): 2-1, 4.30 ERA (14 2/3 IP, 7 ER), 1.36 WHIP, 1 HR, 6 HR, 17 K, 10.4 K/9
Marte (0-1, 4.66 ERA) makes his third MLB start (fifth appearance). The rookie has a 1.40 WHIP, 4.2 BB/9, 5.1 K/9 in 19 1/3 innings.
- Last start: Loss, 4 2/3 IP, 6 ER, 8 H, 1 HR, 3 BB, 2 K in 10-4 loss at Dodgers Saturday
- 2026 home splits (2 starts): 0-0, 0.93 ERA (9 2/3 IP, 1 ER), 1.03 WHIP, 0 HR, 4 BB, 7 K
Dodgers at Giants odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:53 a.m. ET.
- Moneyline (ML): Dodgers -375 (bet $375 to win $100) | Giants +290 (bet $100 to win $290)
- Run line (RL)/Against the spread (ATS): Dodgers -2.5 (-135) | Giants +2.5 (+110)
- Over/Under (O/U): 7.5 (O: +105 | U: -130)
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Dodgers at Giants picks and predictions
Prediction
Dodgers 4, Giants 2
Moneyline
The Dodgers (-375) will cost you nearly 4 times your potential return, and that's super pricey, especially on the road. While, yes, L.A. has a shot at the top playoff seed in the NL, it's way too expensive at this price, especially againts a rookie pitching well at home.
AVOID.
Run line/Against the spread
The GIANTS +2.5 (+110) are catching more than 2 runs and it is plus-money. That's too tempting to pass up.
San Francisco has long since been eliminated, while L.A. is still jockeying for seeding. However, Marte has pitched well at home, and he is auditioning for the 2027 season, and trying to make a big impression. He won't take it easy on the Dodgers.
Over/Under
UNDER 7.5 (-125) is worth a look in this series opener.
The Under has cashed in 4 in a row for San Francisco, averaging just 2.5 runs per game (RPG), while allowing 3.0 RPG in the span.
For L.A., the Under is also 4-0 in the past 4 games, plating 3.4 RPG, while allowing 2.5 RPG in the stretch.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow Daniel Dobish on X at @danieledobish. Follow SportsbookWire on X at SportsBookWire and on Facebook.
This article originally appeared on Sportsbook Wire: Los Angeles Dodgers at San Francisco Giants odds, picks and predictions
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