The New Orleans Saints (1-4) and New York Giants (3-1-1) clash in Week 6. Kickoff is Sunday at 1 p.m. ET from MetLife Stadium in East Rutherford, New Jersey (FOX). Let's analyze NFL odds around the Saints vs. Giants odds and make our expert NFL picks and predictions for the best bets.
The Saints have lost 3 games in a row and had their worst offensive performance last week in a 23-13 home loss to the Minnesota Vikings as 2.5-point underdogs with the Under (41.5) cashing. QB Tyler Shough threw 2 interceptions without a touchdown pass for only 96 yards. They had only 142 total yards of offense after gaining 298 or more in four straight games to open the season.
The Giants are coming off a 27-27 tie with the Washington Commanders as 3.5-point road
underdogs with the Over (41.5) cashing. Jameis Winston threw 2 fourth-quarter touchdown passes to tie the game, passing for 326 yards and 3 TDs. But RB Cam Skattebo fumbled in overtime, and then Washington ran out the clock before anyone could score.
The Saints have won their last 3 meetings with the Giants, including a 26-14 home win last October as 1.5-point favorites with the Under (41.5) cashing.
Watch the NFL on Fubo!
Saints at Giants odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:40 p.m. ET.
- Moneyline (ML): Saints -112 (bet $112 to win $100) | Giants -108 (bet $108 to win $100)
- Against the spread (ATS): Saints -1 (-105) | Giants +1 (-115)
- Over/Under (O/U): 46 (O: -108 | U: -110)
Saints at Giants key injuries
Saints
- LB Kaden Elliss (calf) out
- LB Anfernee Jenkins (knee) out
- RB Alvin Kamara (back) questionable
- WR Chris Olave (illness) questionable
- DT Nathan Shepherd (illness) questionable
- CB Lorenzo Styles (knee) questionable
- LS Zach Wood (calf) questionable
Giants
- OLB Abdul Carter (calf) questionable
- OL Jermaine Eluemunor (calf) questionable
- CB Colton Hood (concussion) out
- TE Theo Johnson (neck) out
- S Tyler Nubin (neck) out
- OL Andrew Thomas (groin) questionable
USA TODAY Sports Fantasy: Sync your ESPN, Yahoo, CBS or Sleeper league in seconds to unlock custom roster advice, expert projections, and start/sit recommendations built for your team. Stop guessing and start winning. Sync your league now!
Saints at Giants picks and predictions
Prediction
Giants 27, Saints 24
Moneyline
The Giants have seen their offense come alive with 36 and 27 points in consecutive weeks. Winston has thrown 3 TD passes in consecutive games.
The Saints allow the second-most points in the league (30.2). Offensively, they have turned the ball over 3 or more times in 3 of their games.
Coach John Harbaugh has got the Giants believing they can win games, and they are taking advantage of struggling teams.
BET GIANTS (-108).
Against the spread
You get better value from the ML, and as the Giants had a tie last week, you won't expect tie in this game, the only way the Giants cover and don't win outright.
PASS
Over/Under
While the Saints give up 30.2 points per game, the Giants have allowed 24 or more in their last 2 games.
Three of the Giants' games and 3 of the Saints' games this season have cleared 46 total points.
BET OVER 46 (-108).
Best prop bet
GIANTS QB JAMEIS WINSTON 2+ TOUCHDOWN PASSES (+115)
Winston has thrown 6 TD passes in his last 2 games, 3 in each. The Saints have allowed 2 or more TD passes to an opponent twice this season.
Betting odds calculator
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow SportsbookWire on X at SportsBookWire and on Facebook.
Access more NFL coverage:
USA TODAY Sports Fantasy | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire | High schools
This article originally appeared on Sportsbook Wire: New Orleans Saints at New York Giants odds, picks and predictions
Advertiser disclosure: USA TODAY may earn a commission when you sign up through links on this page. Commissions never influence our editorial coverage or rankings. Offers and odds were accurate at publication and are subject to change; terms apply — see the operator’s site. This is general information, not betting, legal or financial advice. To the fullest extent permitted by law, USA TODAY is not liable for losses arising from your use of it.
Must be 21+ (18+ where permitted). Sports betting and casino gaming are not legal everywhere; complying with the laws where you are located is your responsibility. Gamble only with funds you can afford to lose. Gambling problem? Help is available 24/7 — call or text 1-800-GAMBLER, or call the National Problem Gambling Helpline at 1-800-MY-RESET. State helplines and responsible gaming resources.
