The San Francisco 49ers (6-0) and Atlanta Falcons (2-4) square off at Mercedes-Benz Stadium in Atlanta, Georgia, on Sunday. Kickoff is scheduled for 1 p.m. ET (FOX). Let's analyze NFL odds around the 49ers vs. Falcons odds and make our expert NFL picks and predictions for the best bets.
The 49ers enter Week 7 coming off a win that showed exactly why they are sitting on top of the NFL world. In a 23-17 win over the Washington Commanders, San Francisco started hot on offense to build an early lead. QB Brock Purdy was 21-for-29 passing for 264 yards with a touchdown. It was RB Christian McCaffrey that doubled up on scores, getting into the end zone twice on the ground.
The Niners offense cooled off after taking a 20-3 lead, but the defense was strong
late against the Commanders. Washington's final 2 drives saw the 49ers force a turnover on downs then a game-ending drive totaling -4 yards for the Commanders.
Likewise to the Commanders, the Falcons got behind even bigger last time out against the Chicago Bears and trailed 31-7. The Falcons made a game of it before losing 31-23, but QB Michael Penix Jr., who had 225 yards and 3 TD passes in the effort, fumbled the ball away late. Falcons rookie WR Zachariah Branch had 2 fumbles in the game as well
Atlanta has been a tough team to gauge through 6 weeks. The Falcons have had 2 ugly losses, 2 dominant wins and 2 frustrating defeats.
The 49ers hold the all-time series against the Falcons 49-33-1. These two faced off just last season with the Niners winning as a 1.5-point favorite and the Under (46.5) hit. While undefeated, San Francisco is 4-2 against the spread this year and 3-3 vs. the point totals. Atlanta has hit the Over in 4 games and also 4-2 ATS.
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49ers at Falcons odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1 p.m. ET.
- Moneyline (ML): 49ers -150 (bet $150 to win $100) | Falcons +125 (bet $100 to win $125)
- Against the spread (ATS): 49ers -2.5 (-118) | Falcons +2.5 (-102)
- Over/Under (O/U): 49.5 (O: -110 | U: -108)
49ers at Falcons
49ers
- DE Nick Bosa (knee, calf) out
- WR Mike Evans (ribs, Achilles) out
- WR Christian Kirk (calf) questionable
- S Siran Neal (knee) questionable
- WR Deebo Samuel (hamstring) out
- S Marques Sigle (ankle) out
- CB Upton Stout (shoulder) questionable
Falcons
- CB Billy Bowman (hamstring) out
- WR Beaux Collins (hip) questionable
- LB Kendal Daniels (neck) questionable
- LB Divine Deablo (forearm) out
- DT Gervon Dexter (hamstring) questionable
- DE Samson Ebukam (hamstring) questionable
- CB CJ Henderson (groin) questionable
- RB Brian Robinson Jr. (hamstring) out
- DE Za'Darius Smith (neck) questionable
- CB AJ Terrell (groin) questionable
- CB Avieon Terrell (back) questionable
- WR Olamide Zaccheaus (shoulder) questionable
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49ers at Falcons picks and predictions
Prediction
49ers 27, Falcons 17
Moneyline
PASS.
With a spread under a field goal, it's worth rolling with the spread instead for some extra juice.
Against the spread
BET 49ers -2.5 (-118)
The Falcons offense turned it on late last week, but the formula for beating them still points toward stopping RB Bijan Robinson. Considering that, this one could mirror Atlanta outing last week as the Niners should move the ball down the field against the Falcons' pass defense ranking fifth-worst in the NFL (252.0 YPG).
Meanwhile, San Francisco's defense mirrors the Bears so far this season, as they rank one position better than the Bears in run defense, allowing just 90.2 YPG (7th in NFL). That should be a good combination leading to a 49ers win and cover.
Over/Under
BET UNDER 49.5 (-108).
While both teams put up some big numbers in recent weeks, both sides do enough leaning on the run game to keep the clock moving and making this a shorter game. That always helps the Under out, especially against a high number like this.
BEST PROP BET
BET BIJAN ROBINSON UNDER 89.5 RUSH YARDS (-115)
In every game the Falcons have lost this season, Robinson has failed to surpass this total. The 49ers have also held an opponent's top rusher under this total in all but one game so far in 2026.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: San Francisco 49ers at Atlanta Falcons odds, picks and predictions
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