The Denver Broncos (2-1) and San Francisco 49ers (3-0) face off Sunday at Levi's Stadium in Santa Clara, California. Kickoff is set for 4:25 p.m. ET (CBS). Let's analyze NFL odds around the Broncos vs. 49ers odds and make our expert NFL picks and predictions for the best bets.
Denver pulled off a 30-26 comeback victory after falling behind 16-0 to the LA Rams on Sunday Night Football in Week 3, covering as a 1.5-point road underdog while the Over (43.5) cashed. After starting out the season with an embarrassing loss to the Kansas City Chiefs, the Broncos have picked up back-to-back come-from-behind wins in spite of how awful their run game has been. The Broncos are averaging just 81 rushing yards per game, and they have just 2 rushing TDs, one
of which came on a QB sneak.
San Francisco continued its dominant start to the season with a 36-30 win over the Arizona Cardinals last Sunday but failed to cover as a 7.5-point home favorite. The Over (48.5) cashed with ease. QB Brock Purdy strengthened his early MVP case in the win, throwing for 297 yards and 4 passing TDs. However, another trend that continued was San Francisco's injury woes as both OT Trent Williams and WR Mike Evans went down early and remained out against Arizona.
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Broncos at 49ers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 2:30 p.m. ET.
- Moneyline (ML): Broncos +125 (bet $100 to win $125) | 49ers -145 (bet $145 to win $100)
- Against the spread (ATS): Broncos +2.5 (-102) | 49ers -2.5 (-118)
- Over/Under (O/U): 48 (O: -108 | U: -110)
Broncos at 49ers key injuries
Broncos
- LB Dondrea Tillman (hamstring) out
49ers
- DE Nick Bosa (knee/calf) out
- LB Jaden Dugger (shoulder) questionable
- WR Mike Evans (ribs) questionable
- LB Dre Greenlaw (quad) questionable
- DT James Thompson Jr. (ankle) out
- DE Keion White (hamstring) questionable
- DE Mykel Williams (knee) out
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Broncos at 49ers picks and predictions
Prediction
49ers 27, Broncos 20
Moneyline
BET 49ERS (-145).
San Francisco's offense is maybe the most potent in the league, putting up 399.3 total yards and 32.7 points per game thus far. That offense will be San Francisco's key to winning. In both of Denver's wins, the Broncos went down by double digits. But that won't work here. This Niners offense is too good and too well-balanced to allow this Denver team to mount a comeback; if the Broncos get down by 2 possessions this game is over.
The injuries are a concern for San Francisco, but the Broncos haven't proven that they can be consistent for an entire game, which would be necessary to come away with a win against such a potent offense.
Against the spread
PASS.
Both teams have avenues to cover here, but neither has the best odds with the spread set at less than a field goal. Pass here and bet on the moneyline and/or total instead as both are more sure bets.
However, if Evans and Williams are able to go, this changes to a LEAN 49ERS -2.5 (-118) because with those both in the San Francisco lineup, the Broncos wouldn't stand much of a chance.
Over/Under
LEAN UNDER 48 (-110).
The Broncos won't be able to run the ball, which will handicap their offense. If Evans is out, the Niners' pass game will be weakened. With both defenses loaded with talent, expect those units to shine more than the offenses in this matchup.
With so many injuries on San Francisco's defense, it is possible that San Francisco's defense doesn't look quite as good, especially the pass rush, so there is a chance that this turns into a shootout if Denver QB Bo Nix gets all day to sit in the pocket.
Best prop bet
BRONCOS RB J.K. DOBBINS UNDER 58.5 RUSHING YARDS (-105).
Only Green Bay rushes for fewer yards per game than Denver's 81.0. Dobbins hasn't even cracked 50 rushing yards in a game yet this season. On the other side, the Niners have an above-average run defense through 3 games in spite of facing Kyren Williams, De'Von Achane, and Jeremiyah Love to start the season.
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This article originally appeared on Sportsbook Wire: Denver Broncos at San Francisco 49ers odds, picks and predictions
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