The Denver Broncos (2-2) and Los Angeles Chargers (0-4) clash on Sunday in Week 5 action in Inglewood, California. Kickoff from SoFi Stadium is at 4:05 p.m. ET (CBS). Let's analyze NFL odds around the Broncos vs. Chargers odds and make our expert NFL picks and predictions for the best bets.
The Broncos, after 2 consecutive wins, were defeated 24-14 last Sunday by the undefeated San Francisco 49ers as 2.5-point road underdogs with the Under (48.5) cashing. They gave up 140 rushing yards, and 49ers QB Brock Purdy threw 2 TD passes.
The Chargers are winless to start the season. Last Sunday, they lost 30-23 on the road to the Seattle Seahawks as 6.5-point underdogs with the Over (42.5) cashing. QB Justin Herbert was sacked four times and intercepted
twice.
The Broncos lead the all-time series with the Chargers 73-58-1 in the regular season. The 2 teams split their season series last year, with the Broncos winning their last meeting 19-3 at home as 15.5-point favorites with the Under (38.5) cashing.
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Broncos at Chargers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:30 p.m. ET.
- Moneyline (ML): Broncos -190 (bet $190 to win $100) | Chargers +155 (bet $100 to win $155)
- Against the spread (ATS): Broncos -3.5 (-110) | Chargers +3.5 (-108)
- Over/Under (O/U): 42 (O: -108 | U: -110)
Broncos at Chargers key injuries
Broncos
- CB Riley Moss (ribs) out
- CB Pat Surtain II (ankle) out
Chargers
- OL Joe Alt (neck) out
- OL Kayode Awosika (fibula) out
- CB Donte Jackson (hamstring) out
- S Derwin James (hamstring) out
- WR Quentin Johnston (chest) out
- TE Charlie Kolar (arm) questionable
- WR Ladd McConkey (foot) questionable
- WR Brenen Thompson (quadriceps) out
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Broncos at Chargers picks and predictions
Prediction
Broncos 23, Chargers 16
Moneyline
Denver head coach Sean Payton has taken over offensive playcalling duties from OC Davis Webb in an attempt to jump-start the offense, which has scored 20 or fewer points 3 times this season.
The Chargers have been held to 16 or fewer points 3 times, and they trailed 30-13 going into the final quarter of their loss to the Seahawks before scoring 10 points in garbage time.
Denver's defense has allowed 24 or more points 3 times, but with the Chargers down so many players with injuries, it's going to be tough for the Los Angeles to overcome that and pick up its first win.
Expect the Broncos to win, but you get better value from the spread.
PASS.
Against the spread
Both of the Broncos' wins were by at least 4 points. The Chargers have lost all 4 games by at least 7. Dating back to last season, they are 0-7 ATS in their last 7 games, including the playoffs.
BET BRONCOS -3.5 (-110).
Over/Under
The total in each of the Chargers' first 3 games was 40. The Over cashed for the first time this season last week (53 points scored with a 42.5 O/U). The Under is 3-1 for the Broncos this season.
BET UNDER 42.5 (-110)
Best prop bet
BRONCOS K WIL LUTZ OVER 1.5 EXTRA POINTS MADE (+160)
The Chargers have allowed 2+ touchdowns in every game this season. Lutz has made 2 PATS in 2 of his last 3 games.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Denver Broncos at Los Angeles Chargers odds, picks and predictions
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