The Detroit Lions (2-2) and Arizona Cardinals (1-3) clash on Sunday in Week 5 in Glendale, Arizona. Kickoff from State Farm Stadium is at 4:25 p.m. ET (FOX). Let's analyze NFL odds around the Lions vs. Cardinals odds and make our expert NFL picks and predictions for the best bets.
The Lions are coming off a 32-26 road loss to the Carolina Panthers last Sunday as 4.5-point favorites with the Over (52.5) cashing. Panthers QB Bryce Young passed for 329 yards and 2 touchdowns and RB Chuba Hubbard rushed for 122 yards and 2 scores against them.
The Cardinals have lost 3 games in a row. They lost 36-24 on the road to the New York Giants last Sunday as 2.5-point favorites with the Over (44.5) cashing. QB Jacoby Brissett was picked off 3 times, the last of which
came on fourth-and-goal on the final play of the game and was returned for a touchdown.
The Lions lead the all-time series against the Cardinals 36-28-6 and are 5-0-1 in their last 6 meetings over the last decade.
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Lions at Cardinals odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1:10 p.m. ET.
- Moneyline (ML): Lions -235 (bet $235 to win $100) | Cardinals +200 (bet $100 to win $200)
- Against the spread (ATS): Lions -5.5 (-108) | Cardinals +5.5 (-110)
- Over/Under (O/U): 54.5 (O: -108 | U: -110)
Lions at Cardinals key injuries
Lions
- OL Ben Bartch (foot) out
- S Brian Branch (Achilles) out
- C Cade Mays (wrist) out
- DL Tyliek Williams (foot) questionable
- CB Rock Ya-Sin (hamstring) out
Cardinals
- OL Isaiah Adams (ankle) out
- WR Marvin Harrison Jr. (trade talks) out
- DL Walter Nolen (calf) questionable
- S Andrew Wingard (knee) out
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Lions at Cardinals picks and predictions
Prediction
Lions 41, Cardinals 31
Moneyline
The Lions have one of the best offenses in the league but also one of the worst defenses. The Cardinals have a solid offense and a terrible defense.
The Lions scored 31 points in each of their first 3 games. The Cardinals were 3 yards from scoring 30 for the second week in a row last Sunday. However, the Cardinals have allowed over 30 points in 3 straight games, and dating back to last season have allowed over 30 points in 9 of their last 13 games, a span in which they have gone 1-12.
The Lions have the second-most sacks in the league while the Cardinals are down 2 starting O-linemen and have an immobile quarterback.
There should be a lot of points scored in this game, but the Cardinals haven't won at home in over a year, haven't beaten the Lions since 2015 and haven't beaten Lions QB Jared Goff since 2016. Goff is 9-1 against the Cardinals with 16 TD passes and 3 rushing TDs in his career.
The Lions win, but the spread gives you better value.
PASS.
Against the spread
While the Cardinals have the capability to keep up with Detroit's offense, if they struggle to protect Brissett and he continues to turn the ball (4 INTs over his last 3 games), they have no chance. They don't get defensive stops and give up too many big plays.
Now with Harrison being deactivated while a trade is being finalized, they will be without their top big-play guy. TE Trey McBride is averaging only 7.3 yards per catch and WR Michael Wilson is averaging only 10.3.
BET LIONS -5.5 (-108).
Over/Under
The Over is 4-0 in Detroit's games this season. The Cardinals have allowed 31 or more points in 3 straight games, and they have scored 24 or more 3 times.
BET OVER 54.5 (-108).
Best prop bet
LIONS K JAKE BATES OVER 3.5 EXTRA POINTS MADE (+140)
Bates has made 4 PATs in 3 of 4 games this season. The Cardinals have given up 4 touchdowns in 3 straight games.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Detroit Lions at Arizona Cardinals odds, picks and predictions
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