The Milwaukee Brewers (93-57) and Pittsburgh Pirates (75-75) open a 3-game series in Pittsburgh, Pennsylvania, Tuesday. First pitch from PNC Park is at 6:40 p.m. ET. Let's analyze MLB odds around the Brewers vs. Pirates odds and make our expert MLB picks and predictions for the best bets.
Season series: Pirates lead 6-4
The Brewers have the best record in the National League and have clinched a playoff berth. They hold a 9 1/2-game lead in the NL Central. They have won 5 of their last 6 games. They were off Monday, but had their 5-game winning streak snapped Sunday in a 4-3 home loss to the Cincinnati Reds as -206 favorites with the Under (8) cashing. RP Antonio Senzatela gave up a 3-run home run to Reds 3B Eugenio Suarez, and RP Abner Uribe allowed
a go-ahead RBI double to C Tyler Stephenson in the eighth inning.
The Pirates have been eliminated from playoff contention. They have won 10 of their last 14 games, and they snapped a 2-game skid Sunday with a 4-3 win at the Chicago Cubs as +141 underdogs with a push for the total (7). PH-2B Brandon Lowe hit a 2-run double as part of a 3-run sixth inning.
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Brewers at Pirates projected starters
RHP Jacob Misiorowski vs. RHP Lake Bachar
Misiorowski (14-5, 1.95 ERA) makes his 28th start. He has a 0.80 WHIP, 2.3 BB/9 and 13.2 K/9 in 161 1/3 innings.
- Last start: No-decision, 6 1/3 IP, 1 ER, 4 H, 2 BB, 9 K in 4-3 10-inning home win over Chicago Cubs last Tuesday
- Last start vs. Pirates (April 25): No-decision, 6 IP, 3 ER, 6 H, 1 BB, 9 K in 6-3 10-inning home loss
- Career vs. Pirates: 2-0, 2.00 ERA (18 IP, 4 ER), 0.89 WHIP, 12.5 K/9 in 3 starts
- 2026 road splits: 7-4, 2.39 ERA (71 2/3 IP, 19 ER), 0.84 WHIP, 12.1 K/9 in 12 starts
Bachar (1-3, 3.52 ERA) makes his 10th start and 49th appearance. He has a 1.10 WHIP, 3.7 BB/9 and 9.4 K/9 in 79 1/3 innings.
- Last start: No-decision, 1 2/3 IP, 0 ER, 2 H, 1 BB, 3 K in 4-2 win at Chicago White Sox Wednesday
- Career vs. Brewers: 0-1, 1.50 ERA (6 IP, 1 ER), 1.17 WHIP, 7.5 K/9 in 6 games (1 start)
- 2026 home splits: 0-1, 2.02 ERA (35 2/3 IP, 8 ER), 0.90 WHIP, 10.1 K/9 in 21 games (5 starts)
Brewers at Pirates odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:10 a.m. ET.
- Moneyline (ML): Brewers -275 (bet $275 to win $100) | Pirates +220 (bet $100 to win $220)
- Run line (RL)/Against the spread (ATS): Brewers -2.5 (+115) | Pirates +1.5 (-140)
- Over/Under (O/U): 7.5 (O: -110 | U: -110)
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Brewers at Pirates picks and predictions
Prediction
Brewers 5, Pirates 2
Moneyline
The Brewers are 9-1 in Misiorowski's last 10 starts and 6-0 in his last 6. They are 12-6 in their last 18 games.
The Pirates are 3-0 in Bachar's last appearances, all as openers, but he hasn't lasted longer than 2 1/3 innings in those games.
Milwaukee is 41-31 on the road and 41-28 against teams with at least a .500 record like the Pirates.
Expect the Brewers to win, but the value is much better betting the run line for either team.
PASS.
Run line/Against the spread
Thirteen of the Brewers' last 18 wins have been by 3 or more runs. Thirteen of their 19 wins in Misiorowki's starts have been by 3 or more runs.
Five of the Pirates' last 7 losses have been by 3 or more runs.
BET BREWERS -2.5 (+115).
Over/Under
Five of Misiorowski's last 7 starts have had totals of 7 or below.
Eight of the Pirates' last 10 games have had 7 or fewer total runs.
BET UNDER 7.5 (-110).
Best prop bet
Lake Bachar UNDER 0.5 earned runs allowed (+115)
Bachar has not allowed a run in 7 of his 9 appearances with the Pirates, including his last 2 starts. He has not allowed a run in 5 of his 9 games as an opener.
Betting odds calculator
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This article originally appeared on Sportsbook Wire: Milwaukee Brewers at Pittsburgh Pirates odds, picks and predictions
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